PROSTATE CANCER AND EPISTAXIS (original) (raw)
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Cases Journal, 2009
Background Incidental carcinoma of the prostate gland is a common clinical problem among elderly males but this malignancy presenting initially with features of Disseminated Intravascular Coagulopathy (DIC) in the African blacks is rare. Disseminateded intravascular coagulathy is the most frequent coagulation disorder in patients with prostate cancer, However DIC as a first manifestation of prostate cancer is unusual. Case report This paper reports a case of a 56 year old Nigerian civil servant who presented initially with clinical features of DIC characterised by bleeding from multilple orifices but was subsequently diagnosed at autopsy to be infiltrating adenocarcinoma of the prostate. Conclusion This rare case of DIC should be considered especially in elderly men when no other cause can be found for coagulopathy.
Unusual presentations of prostate cancer: A review and case reports
2013
To report our institutional experience with some rare presentations of prostate cancer, as prostate cancer is a common problem and affects a large group of men during their lifetime, but a few studies report unusual presentations of metastatic prostate cancer. Methods: All possible clinical and pathological data were collected for six relevant patients with prostate cancer and unusual metastases who were identified at our institution. PubMed was searched for unusual presentations of prostate cancer in the last 20 years (1982-2012) and all relevant publications were assessed. The authors discussed the reports and selected those articles of major clinical significance to include in a review. Results: We identified 19 reports of major clinical significance and reviewed them. As in the cases from our institution, supraclavicular lymphadenopathy, isolated upper ureteric obstruction and severe obstructing constipation were some of the rare presentations encountered at other institutions, and reported mostly as sporadic case-reports. Conclusion: Prostate cancer should be always considered in the differential diagnosis of elderly men presenting with supraclavicular lymphadenopathy, hydroureteronephrosis or constipation, even in the presence of a normal digital rectal examination and low serum total prostate-specific antigen (PSA) levels. PSA immunohistochemical staining should be used in doubtful cases.
Prostate Gland and Related Disorders
Geriatric Diseases, 2017
The transition zone of the prostate enlarges with age by developing benign prostatic hypertrophy, and the proliferative process occurs exclusively in the transition zone and periurethral glands. Benign prostate hypertrophy (BPH) is a common part of ageing, and by the age of 80 years, about 90% of the men will have histological evidence of BPH. The diagnosis is based on the history followed by digital rectal examination (DRE) which is an integral part in the evaluation. Prostatitis is an inflammatory disorder, bacterial or nonbacterial and can be acute or chronic. Prostatic abscess is a focal accumulation of pus within the prostate. Carcinoma of the prostate is the commonest malignancy among elderly men affecting 30% of men at the age of 50 and 90% at the age of 90 years. The review summarises the main group of prostate disorders with the main focus on the management.
Prostate pathology case study seminar
Virchows Archiv, 1997
Great strides have been made in the past decade in our understanding of the pathology of the prostate. Diagnostic criteria have been proposed, debated, and refined for a number of entities, including prostatic intraepithelial neoplasia, atypical adenomatous hyperplasia, basal cell proliferations, postatrophic hyperplasia, verumontanum mucosal gland hyperplasia, and numerous new variants of prostatic adenocarcinoma such as ductal adenocarcinoma, mucinous carcinoma, signet ring cell carcinoma, and lymphoepithelioma-like carcinoma. This report presents a series of case studies in prostate pathology which illustrate some of the contemporary issues which confront the pathologist and urologist.
Urology, 2013
A 57-year-old man with a history of prostate cancer treated with robot-assisted laparoscopic prostatectomy and subsequent salvage pelvic irradiation was referred to our institution with a 2-year history of intermittent pelvic pain and recurrent symptomatic urinary tract infections (UTIs). He had significant worsening perineal pain refractory to conservative treatment, intermittent gross hematuria, and total urinary incontinence. His medical history was significant for diabetes, hypertension, hyperlipidemia, and morbid obesity with a body mass index of 44 kg/m 2. He had been diagnosed with prostate cancer and treated operatively 3 years before the present evaluation. His preoperative prostatespecific antigen (PSA) level was 9.8 ng/mL. The postoperative pathologic finding was Gleason grade 3+4 with a 4-mm positive margin at the apex. Extended bilateral pelvic lymph node dissection revealed no metastatic disease. His initial postoperative PSA level was undetectable; however, he developed PSA recurrence 12 months after surgery. He subsequently received 35 fractions of high-dose (78 Gy) salvage radiotherapy to the prostate bed during an 8-week period. His PSA values have been undetectable since then. The review of his systems was negative, except as above. The physical examination findings were significant only for suprapubic and pelvic girdle tenderness. Knee flexion produced perineal pain, but he was without sensory or motor deficits. Because his PSA values had been undetectable, the differential diagnosis focused on nononcologic etiologies for his pelvic pain and recurrent UTIs. As an initial step in his evaluation, laboratory assessments were performed. A complete blood count revealed a mildly elevated white blood cell count of 12,400/μL. The other parameters on his complete blood count were normal. His urinalysis demonstrated 235 red blood cells/high power field
Gastroenterology Research, 2010
Rectal bleeding is often seen in patients who undergo transrectal ultrasound-guided prostate biopsy. It is usually mild and stops spontaneously. We report what we believe is the first case of life threatening rectal bleeding following this procedure which was successfully treated with angiographic embolization. An endoscopic injection of epinephrine done on admission achieved only temporary hemostasis and the patient developed a second episode of massive rectal bleeding that warranted angiographic treatment. We present this case in detail and review other alternatives for treating fulminant rectal bleed which is a consequence of this procedure.
World Journal of Cardiovascular Diseases, 2020
Introduction: Deep vein thrombosis is a frequent disease, its origin is most often multifactorial. Venous thromboembolic disease (MVTE) and cancer are two frequently entangled pathologies. Here we report the diagnosis of deep vein thrombosis that discovered prostate cancer in an 88-year-old Guinean man. On clinical examination, there was a painful and hot swelling of the right leg, an absence of sloshing of the calf, a positive sign of Homans. The digital rectal examination revealed an enlarged prostate with an irregular surface. Cardiopulmonary auscultation was normal. The electrocardiogram showed a regular sinus rhythm at 65 cycles/min, with no sign of enlarged cavities or conduction disturbance. Venous Doppler ultrasound of the lower limbs showed the presence of an extensive acute deep venous thrombosis of the right sural vein extended to the popliteal and to the homolateral deep femoral. The reino-vesico-prostatic ultrasound concluded in a heterogeneous prostatic hypertrophy with projection of a median lobe associated with a bladder of fight with an important post voiding residue evaluated at 170 ml; the rate of specific antigen of the prostate PSA was at 84.87 ng/ml. The pathology analysis made after a prostate biopsy puncture concluded with an adenocarcinoma with a Gleason score of 3. Conclusion: The
Clinical spectrum of prostatic lesions: A clinicopathological study
Introduction: Prostatic disease is responsible for significant morbidity and mortality in men, throughout the world. Currently, there is an increasing trend of the particularly in the elderly. Amis and objectives: clinical data. Materials and Method: Medical College, Latur during period of Nov 2010 to Oct 2012. All the prostate specimens referred to department of pathology for histopathological diagnosis were included. Detail clinical data were noted f Includes age of patients, presenting symptoms, Digital Rectal Examination (DRE) findings and relevant investigations like serum PSA levels, USG and clinical diagnosis. lesions 6.36% in this study. In benign lesions, maximum (43.69%) cases were found in the age group of 61 to 70 years. The most common chief complaint was frequency (46.60%), malignant lesions, maximum (57.14%) c nocturia and retention in 42.86% cases followed by frequency and urgency in 28.57% and hesitancy in 14.28% patient respectively. Hematuria and intermittent stre...