Triptolide Induces Pancreatic Cancer Cell Death via Inhibition of Heat Shock Protein 70 (original) (raw)
Heat Shock Protein 70 Increases Tumorigenicity and Inhibits Apoptosis in Pancreatic Adenocarcinoma
Rajinder Dawra
Cancer Research, 2007
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Mouse Pancreatic Cancer Cells from KRASG12D/P53−/− Transgenic Mice Overexpress Heat Shock Protein 70 (HSP70), and Its Inhibition by Triptolide Decreases Cell Viability
Yumi Yokoyama
Pancreas, 2008
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Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures
Simonas Daunys
Scientific Reports, 2019
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The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer
Seiji Adachi
International Journal of Molecular Sciences, 2016
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Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways
Rajinder Dawra
Gastroenterology, 2010
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Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2
Mikkel Rohde
Proceedings of the National Academy of Sciences, 2000
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Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis
Eric Kampmann
Journal of cellular and molecular medicine, 2015
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TRAIL and Triptolide: An Effective Combination that Induces Apoptosis in Pancreatic Cancer Cells
Rajinder Dawra
Journal of Gastrointestinal Surgery, 2010
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Targeting heat shock proteins in cancer
Gaetan Jego
Cancer Letters, 2013
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Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3
Vladimir Mitkevich
International journal of molecular sciences, 2018
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Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms
Rajinder Dawra
Gastroenterology, 2009
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Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo
Chitra Mandal
International Journal of Cancer, 2013
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A modified HSP70 inhibitor shows broad activity as an anticancer agent
Jude Caesar Lucero Villanueva
Molecular Cancer Research, 2013
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Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor
Wendy Frankel
Clinical Cancer Research, 2008
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Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer
Palma Rocchi
Cancer Letters, 2012
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Targeting heat shock response pathways to treat pancreatic cancer
Palma Rocchi
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Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway
Selwyn Vickers
Cancer Letters, 2014
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HSP27 and HSP70: Potentially Oncogenic Apoptosis Inhibitors
celine cande
Cell Cycle, 2003
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A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
Andrew J Massey
Cancer Chemotherapy and Pharmacology, 2010
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Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated by O-GlcNAc Modification of Transcription Factor Sp1
Veena Sangwan
Journal of Biological Chemistry, 2013
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Targeting Hsp70: A possible therapy for cancer
Manoj Mishra
Cancer letters, 2016
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Heat Shock Protein 70 Is Required for the Survival of Cancer Cells
Jesper Nylandsted
Annals of the New York Academy of Sciences, 2006
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Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma
Eloisi Lopes
Hepatology, 2009
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The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer
Seiji Adachi
Oncotarget, 2016
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Hsp70 in cancer: A double agent in the battle between survival and death
Shirafkan Kordi
Journal of Cellular Physiology, 2020
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Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth
Nirmala Jagadish
BMC cancer, 2016
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