Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells (original) (raw)
The role of HIV1 Nef in T-cell activation: Nef impairs induction of Th1 cytokines and interacts with the Src family tyrosine kinase Lck
Yves Collette
Research in Virology, 1997
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Nef-Induced CD4 Degradation
Nicolas Demaurex
Cell, 1999
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Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes
Victor Garcia
Retrovirology, 2012
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Simian Immunodeficiency Virus Nef Protein Delays the Progression of CD4+ T Cells through G1/S Phase of the Cell Cycle
Hau Nguyen
Journal of Virology, 2002
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Effects of the exogenous Nef protein on HIV-1 target cells
Caterina Martini
Cell Biochemistry and Function, 1999
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HIV-1 Nef control of cell signalling molecules: Multiple strategies to promote virus replication
Dale McPhee
Journal of Biosciences, 2003
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Determinants in HIV1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo
Serkan Sertel
Retrovirology, 2009
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HIV: A new role for Nef in the spread of HIV
Mark Harris
Current Biology, 1999
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HIV Type 1 Nef Is Released from Infected Cells in CD45 + Microvesicles and Is Present in the Plasma of HIV-Infected Individuals
Md. Mahfuz Khan
AIDS Research and Human Retroviruses, 2011
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Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef
Gaurav Shrivastava
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Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo
Jean-Charles Grivel
Journal of virology, 1999
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Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice
Donald Mosier
Journal of virology
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HIV-1 Nef Transfer and Intracellular Signalling in Uninfected Cells
Elisabetta Affabris
HIV-Host Interactions, 2011
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Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV1
Mario Santiago
Cell, 2006
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Nef Deletion in HIV-1eli Eliminates Peripheral CD4 T-Cell Loss in a Humanized BLT Mouse Model of HIV Disease
Subhagya Wadekar
International Journal of Drug Development and Research, 2016
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CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells
Stefania Petrini
Journal of General …, 2011
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Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis
MARY MORENO
Journal of virology, 2003
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Human Immunodeficiency Virus Type 1 Nef Mediates Sustained Membrane Expression of Tumor Necrosis Factor and the Related Cytokine LIGHT on Activated T Cells
Juan Lamas
Journal of Virology, 2000
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HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic mice
Patrick Vincent
Virology, 2006
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HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice
Masaru Taniguchi
International Immunology, 2011
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HIV-1 Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism
Elaine Dzierzak
Genes and Function, 1997
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Inefficient Nef-Mediated Downmodulation of CD3 and MHC-I Correlates with Loss of CD4+ T Cells in Natural SIV Infection
Mohammed khalid
PLoS Pathogens, 2008
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Adult AIDS-Like Disease in a Novel Inducible Human Immunodeficiency Virus Type 1 Nef Transgenic Mouse Model: CD4+ T-Cell Activation Is Nef Dependent and Can Occur in the Absence of Lymphophenia
Mir Rahim
Journal of Virology, 2009
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HIV-1 Nef Induces the Release of Inflammatory Factors from Human Monocyte/Macrophages: Involvement of Nef Endocytotic Signals and NF- B Activation
Elisabetta Affabris
The Journal of Immunology, 2003
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Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection
Maria Jamur
PLoS ONE, 2014
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specific Nef interference with HIV1-specific CTL antiviral activity is epitope
Ayub Ali
2010
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