The oral route in the pathogenesis of paracoccidioidomycosis: An experimental study in BALB/c mice infected with P. brasiliensis Conidia (original) (raw)
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Paracoccidioidomycosis: a series of 66 patients with oral lesions from an endemic area
Mycoses, 2011
America. It has been regarded as a multifocal disease, with oral lesions as the prominent feature. To provide useful information concerning the diagnosis and management of the disease, this study describes demographic and clinical data from the medical records of a consecutive series of 66 Brazilian patients from an endemic area, evaluated in a referral centre for oral diagnosis. In this sample of patients, there was a predominance of middle-aged male patients, who were primarily rural workers. Chronic multifocal disease was prevalent, with lesions also detected in the lungs, lymph nodes, skin or adrenal glands. Most of the cases presented with lesions at the gingival mucosa followed by the palate and lips; these conditions occurring in the oral cavity were frequently associated with pain. Importantly, most of the patients sought professional care for oral lesions. The diagnosis was obtained through exfoliative cytology and ⁄ or biopsy of the oral lesions. Medical treatment was effective, and there were no mortalities in the sample. The present findings not only confirm the importance of oral lesions in the diagnosis and management of PCM but also illustrate that questions still remain unclear, such as the possibility of direct inoculation of the fungus onto oral tissues.
Oral Paracoccidioidomycosis: A Case without Lung Manifestations
The Journal of Contemporary Dental Practice, 2007
Aim The aim of this article is to present a case of Paracoccidioidomycosis with involvement of the oral cavity but without pulmonary manifestations. Background Paracoccidioidomycosis is a fungal infection caused by Paracoccidioides brasiliensis. It is an endemic disease representing a serious health problem for Latin American countries, especially Brazil. This infection primarily affects the lungs of adult men and is acquired through inhalation or accidental inoculation of the fungus. It can spread to other organs and tissues, mainly the oral cavity. Administration of antifungal medication always resolves the disease. Report A 58-year-old black male presented with three painless, ulcerated, mulberry-like granulomatous lesions located in the floor of the mouth, on the superior alveolar ridge, and on the hard palate, which had evolved over a period of two years. Facial asymmetry was observed due to edema in the lower lip and lymphadenopathy. He had smoked for more than six years but s...
Mycoses, 2003
The present study describes 21 Argentinian patients living in the province of Corrientes, who had developed oral manifestations due to Paracoccidioides brasiliensis infection. Of these, 20 patients were men and one a woman. Patients were of an average age of 39 years (range 25 to 72 years). Approximately, 76.2% of the patients were farmers. Gingival lesions were observed in 76%. Also, the tongue (71%) and the lips (62%) were frequently affected. Cytological smears and histopathology showed the characteristic fungal cells with the characteristic granulomatous inflammatory reaction consisting of lymphocytes, epithelioid cells and giant cells of the Langhans type. All patients except one had detectable pulmonary involvement. Therapy consists of long-term administration of itraconazole. Oral manifestations of paracoccidioidomycosis are characteristic in their clinical presentation. Early diagnosis and adequate therapy may prevent extensive tissue destructions. Long-term follow-up is mandatory.
Paracoccidioidomycosis in a 64-year-old man: a case report
Brazilian Journal of Development
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the thermo-dependent dimorphic fungus Paracoccidioides spp, limited to the American continent, but with a high incidence in Brazil, mainly in the Midwest, South and Southeast regions. This is a case report of a 64-year-old male patient that was referredat a hospital, complaining of pain in the mouth and dysphagia. The patient presented multiple and finely granular hemorrhagic pinpoint erosions with a mulberry-like appearance in oral mucosa. The patient underwent an incisional biopsy, and the histopathological analyses confirmed the presence of the fungus and the diagnosis of PCM. Lesions in oral mucosa may be the first visible clinical manifestation of PCM; so, a meticulous evaluation of oral cavity and well-conducted diagnostic techniques are indispensable for a correct diagnosis and an appropriate therapy of PCM.
International journal of odontostomatology, 2014
This article describes a case of recurrence of chronic paracoccidioidomycosis (PCM) 11 years following the initial diagnosis. The patient was a 51-year-old white Brazilian female, which had been previously diagnosed with PCM. The physical examination revealed the presence of a single crusted lesion in the upper lip and an elevated lesion with fibrous scar appearance on right buccal mucosa. Although the diagnosis of PCM, the absence of pulmonary involvement led to the biopsy of the lesion localized on the buccal mucosa and the histopathological analysis in H&E and PAS stains revealed no morphological changes suggestive of any lesion. However, the exfoliative cytology stained with Grocott-Gomori showed the presence of Paracoccidioides brasiliensis and the infection caused by this fungus was proven. Of this way, we emphasize the importance of stomatologic evaluation to the diagnosis of diseases that usually manifestssystemically. So, the correct diagnosis of oral manifestations of PCM, is essential to ensure early and safe intervention.
Single Oral Paracoccidioidomycosis Mimicking Other Lesions: Report of Eight Cases
Mycopathologia, 2012
Paracoccidioidomycosis is a fungal infection caused by Paracoccidioides brasiliensis. It is an endemic disease, representing a serious health problem in Latin American countries. This infection primarily affects the lungs and is acquired by inhalation of the fungus. It can spread to other organs and tissues, mainly the oral cavity affecting more adult men from 30 to 50 years of age. On clinical presentation, several signs associated with impaired general and nutritional conditions can be noted. Oral manifestation is more common in the soft palate, gingiva, lower lip, buccal mucosa, and tongue. The classical clinical presentation is a superficial ulcer with granular appearance and hemorrhagic points. Usually, the oral lesion is extensive and generalized. Although uncommon, when the oral manifestation is single, others lesions, particularly squamous cell carcinoma, must be included in the differential diagnosis. In this article, the authors discuss the unusual presentation of eight cases of single oral paracoccidioidomycosis and its diagnostic importance.
Gingival Involvement in Oral Paracoccidioidomycosis
Journal of Periodontology, 2007
Background: Paracoccidioidomycosis, a deep mycosis endemic in parts of Latin America, often presents with oral lesions involving the gingiva. Nevertheless, the periodontal literature is devoid of references to oral paracoccidioidomycosis. The purpose of this study was to characterize the gingival involvement in oral paracoccidioidomycosis and to contrast clinical and histopathologic diagnosis of the disease. Differential diagnosis and management of oral paracoccidioidomycosis were reviewed.
Value of exfoliative cytology in diagnosis of oral paracoccidioidomycosis - case report
Polski Przegląd Otorynolaryngologiczny, 2016
Paracoccidioidomycosis is a systemic mycosis caused by inhalation of the fungus P. brasiliensis. The primary infection involves the lungs and can spread to other organs and systems resulting in secondary lesions in the mucosa, lymph nodes, skin and adrenal glands. Oral lesions are insidious in progression and can be multifocal. The aim of this study was to report a case of paracoccidioidomycosis in a patient who was misdiagnosed with pulmonary tuberculosis. A 40-year-old male, HIV-positive, was admitted with complaints of weight loss, asthenia, diarrhea, coughing and dyspnea. Physical examination revealed the presence of caries, coated tongue, residual roots, oral candidiasis and ulcerated, granulomatous lesions in the hard palate and alveolar ridge. Laboratory tests revealed anemia, neutrophilia and an increased erythrocyte sedimentation rate. Cytology and incisional biopsy were performed. The cytological examination revealed the presence of fungus and the pathological examination confirmed the diagnosis of paracoccidioidomycosis. The doctors who previously made the diagnosis of tuberculosis were informed of the new diagnosis, as the patient was being treated for tuberculosis. The treatment for paracoccidioidomycosis was initiated and the patient is under clinical monitoring.
Unusual Intestinal Involvement by Paracoccidioidomycosis Diagnosed After Oral Manifestation
Mycopathologia, 2018
Paracoccidioidomycosis is a common deep fungus infection in South America, particularly in Brazil. It is acquired through inhalation and primary involvement of lungs. Subsequently, dissemination may occur and oral mucosa is frequently affected and actually, in most of the cases the diagnosis is established because of the oral lesions. Thus, the role of the dentist is fundamental to correct diagnosis. However, the involvement of intestine is rarely reported. The current case describes a 36-year-old man who presented abdominal pain and intestinal constipation, being suspected and then confirmed as paracoccidioidomycosis after already be diagnosed with this disease by a dentist through oral manifestations.