In vitro genotoxicity assessment of non-photoactivated hypericin (original) (raw)

Non-photoactivated hypericin, sourced from Saint John’s Wort, exhibits no significant genotoxic effects across various experimental models, including bacterial assays, yeast assays, and mammalian cell lines. It demonstrated non-mutagenicity in Salmonella typhimurium and Chlamydomonas reinhardtii, while also showing no significant alterations in chromosome aberrations. Though it slightly inhibited mutagenicity in some cases, the overall findings suggest that non-photoactivated hypericin poses minimal genotoxic risk, contrasting with the phototoxic effects associated with its photoactivated form.