Regulation of pacemaker frequency in the murine gastric antrum (original) (raw)

Current research highlights the role of interstitial cells of Cajal (ICC) in generating slow-wave activity in gastrointestinal muscles, particularly in the murine gastric antrum. The study reveals that these ICC generate spontaneous inward currents linked to slow-wave activity and that the regulation of this activity is modulated by various factors, including prostaglandin E2 (PGE2) through different receptor pathways (EP 2, EP 3, EP 4). Findings suggest that EP 3 receptor stimulation enhances slow-wave frequency in intact gastric muscles, with potential implications for understanding and treating gastric arrhythmias and disorders related to normal gastrointestinal rhythm.