Clinical, laboratory, diagnostic and prognostic aspects of canine lymphoma: a retrospective study (original) (raw)
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Veterinaria México OA, 2019
Non-Hodgkin’s lymphomas are common canine cancers with variable demographic and clinical presentations. Their pathological characterization and treatment lag far behind those of humans. We describe consecutive lymphoma patients detected over a one-year period at the National Autonomous University of Mexico (UNAM). Of 4,512 dogs: 220 (4.9%) had a cancer diagnosis, of which 27 (0.6%) had lymphoma (12% of cancer patients). We found an association with Miniature Schnauzers, which represented 18.5% (5/27) of lymphoma patients, but it was only 6.4% (288/4,512) of the dogs studied in this time period (p
Successful Medical Management of Lymphoma in Six Dogs
Indian Journal of Animal Research, Volume 58 Issue 2: 276-280 (February), 2024
Background: Lymphoma is considered to be the most common hematopoietic tumor in dogs (83%) having an overall cure rate of less than five percent. Although many chemotherapy protocols have been suggested, doxorubicin based combination protocols are widely associated with long disease free interval and improved duration of survival. Six dogs presented to Madras Veterinary College Teaching Hospital with clinical signs suggestive of lymphoma were taken up for this study. Methods: The dogs were subjected to detailed clinical examination and dermatological examination. Fine needle aspiration cytology (FNAC) samples were taken from the lymph nodes in cases of multicentric lymphoma and from cutaneous nodules in cases of cutaneous lymphoma. Tru-cut biopsy and impression smears were collected from the cutaneous nodules. The FNAC and impression smears revealed pleomorphic lymphocytes suggestive of lymphoma. Ultrasonographic examination of all dog revealed the enlargement of mesenteric lymph nodes and spotted appearance of spleen. Treatment with multi-agent chemotherapeutic protocol (University of Wisconsin-Madison, Lymphoma CHOP-19 protocol) was initiated after confirmative diagnosis. Result: Remissions in clinical signs were noticed within a week of therapy and no evidence of peripheral lymph node enlargement could be appreciated after three weeks of therapy. The diagnostic and management plans were presented and discussed.
The diagnostic assessment of canine lymphoma: implications for treatment
Clinics in laboratory medicine, 2011
Lymphoma in dogs is a heterogeneous cancer with highly variable prognosis. Many types of canine lymphoma have similar counterparts in the World Health Organization classification of human lymphoid tumors. The most common variant of canine lymphoma is diffuse large B-cell lymphoma, which, if treated with multiagent chemotherapy, has a survival time of approximately 12 months. T-cell lymphomas are more heterogeneous and high- and low-grade variants are common, which necessitates classification beyond B- versus T-cell lineage.
Lymphoma (malignant lymphoma, lymphosarcoma) in the dog
Journal of Small Animal Practice, 1992
This report describes seven cases of canine lymphoma involving three German shepherd dogs, two boxers and two mongrels with a male to female ratio of 1.3 to 1. Their mean age and bodyweight was four years (range 1.5 to 8) and 31 kg (range 2 1 to 40), respectively. Six of the animals were euthanased at their owner's request and one died. Excessive lymph node enlargement, splenomegaly, hepatomegaly, blood lymphocytosis and proteinuria were the most striking clinical and clinicopathological findings. All the cases except one presented systemic signs and three developed secondary leukaemia because of bone marrow involvement. The anatomical types were classified according to the World Health Organization's criteria as thymic (one dog) and generalised (six dogs) and the clinical stage as IV (four dogs) and V (three dogs). Extranodal lymphomas involving the kidneys, meninges and the alimentary tract were seen in two cases. Histologically, the lymphomas were classified as lymphoblastic in four dogs, and in the remaining animals as lymphoblastic with plasmacytoid differentiation, lymphocytic with plasmacytoid differentiation, and poorly differentiated (stem cell) with one type appearing in each dog.
Journal of Veterinary Medicine Series A, 2002
Sixty-three dogs with multicentric lymphoma were evaluated for risk of diseases. The greatest risk of disease concerned rottweilers as compared to other breeds (odds ratio 6.01 to 0.32-2.75, respectively). A group of 43 dogs under chemotherapy was evaluated for defining factors influencing first remission time duration and survival time. The most important factors for results of chemotherapy were response to therapy, stage and sub-stage of disease according the World Health Organization staging system at the time of diagnosis.
Veterinary Pathology, 2010
This study reports cytomorphological, histomorphological, and immunological characterization of 608 biopsy cases of canine malignant lymphoma, with epidemiological and clinical data, collected from 7 French veterinary pathology laboratories. It compares morphological characteristics of malignant lymphoma in canines, per the updated Kiel classification system, with those reported in humans, per the World Health Organization (WHO) classification system. Of tumors described, 24.5% and 75.5% were classified as low-and high-grade malignant lymphomas, respectively. Presenting clinical signs included generalized or localized lymphadenopathy (82.4%) and extranodal diseases (17.6%) involving the skin (12.34%) and other sites (5.26%). Immunohistochemistry confirmed 63.8% B-cell (CD3-, CD79aþ), 35.4% T-cell (CD3þ, CD79a-), and 0.8% null-cell (CD3-, CD79a-) lymphomas. Most B-cell cases (38.49%) were of high-grade centroblastic polymorphic subtype; most T-cell cases (8.55%), high-grade pleomorphic mixed and large T-cell lymphoma subtypes. Some B-cell tumors showed morphologic characteristics consistent with follicular lymphomas and marginal zone lymphomas per the Revised European American Classification of Lymphoid Neoplasms and WHO canine classification systems and the WHO human classification system. Unusual high-grade B-cell subtypes included an atypical high-grade small B-cell lymphoma (0.66%), Burkitt-type B-cell lymphoma (1.64%), plasmacytoid lymphoma (0.99%), and mediastinal anaplastic large B-cell lymphoma (0.16%). Unusual T-cell subtypes included a previously undescribed high-grade canine immunoblastic T-cell type (1.15%), a rare low-grade prolymphocytic T-cell lymphoma (0.16%), and a recently described high-grade canine T-cell entity-aggressive granulocytic large-cell lymphoma (0.16%). Marginal zone lymphomas were common (10.86%); follicular lymphomas were rare (0.49%). Canine primary cutaneous malignant lymphoma subtypes were present (11.84%). There was no significant difference between B-and T-cell malignant lymphoma in regard to canine age and sex. A significant overrepresentation of Boxers (24.19%) was found for T-cell lymphomas.
Epidemiology, clinical and cytological features of lymphoma in Boxer dogs
Acta Veterinaria Hungarica, 2019
The aim of this study was to evaluate the epidemiology, clinical and laboratory characteristics of canine lymphomas as well as some aspects of treatment outcomes. The study was conducted on Boxer dogs with lymphoma diagnosed by cytology and immunocytochemistry (CD3 and CD79 alpha). During the study period, lymphoma was diagnosed in 63 Boxers; 86.8% were T-cell (based on the Kiel classification: small clear cell lymphoma, pleomorphic small cell lymphoma, pleomorphic mixed T-cell lymphoma, pleomorphic large T-cell lymphoma, lymphoblastic lymphoma/acute lymphoblastic leukaemia) and 13.2% were B-cell lymphomas (according to the Kiel classification: B-cell chronic lymphocytic leukaemia, centroblastic/centroblastic polymorphic lymphoma). Overall survival (OS) was significantly longer in dogs with low-grade than with high-grade lymphoma (median OS of 6.8 and 4.7 months, respectively; P = 0.024). OS was not influenced by WHO clinical stage, WHO clinical substage, presence of splenomegaly, e...
Immunohistochemical Characterization of Canine Lymphomas
Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 2017
Lymphomas occur by clonal expansion of lymphoid cells and have distinctive morphological and immunophenotypic features. Determination of canine lymphoma immunophenotype is useful for accurate prognosis and further therapy. In the suggested study, we performed an immunohistochemical evaluation of some cases with canine lymphoma diagnosed in the Department of Pathology (Faculty of Veterinary Medicine, Cluj-Napoca, Romania), in order to characterize them. The investigation included 39 dogs diagnosed with different anatomical forms of lymphoma, following necropsy analysis or assessment of biopsies. The diagnosis of lymphoma was confirmed by necropsy and histopathology (Hematoxylin-eosin stain) examinations. The collected specimens were analyzed by immunohistochemistry technique (automatic method) using the following antibodies: CD3, CD20, CD21 and CD79a. The analyzed neoplasms were characterized as follows: about 64.10% of cases were diagnosed as B-cell lymphomas, 33.34% of cases as T-cell lymphomas, whereas 2.56% of cases were null cell type lymphomas (neither B nor T). Most of multicentric (80%), mediastinal (60%) and primary central nervous system lymphomas (100%) had B immunophenotype, while the majority of cutaneous (80%) and digestive (100%) lymphomas had T immunophenotype. Immunohistochemical description of canine lymphomas can deliver some major details concerning their behavior and malignancy. Additionally, vital prognosis and efficacy of some therapeutic protocols are relying on the immunohistochemical features of canine lymphoma.
Histopatological diagnosis of canine and feline lymphoma
There are several options on how to get a sample intended for diagnosis and determined by the pathologist. Each technique has its advantages and disadvantages for both the clinician and the pathologist. The purpose of this work is to review the advantages (10 cases in dogs and 10 cases in cats) and the difficulties in veterinary practice regarding cytology (5 dogs and 5 cats) and biopsy-based diagnosis of lymphoma (5 dogs and 5 cats). We described 20 cases of lymphoma: ten cases were diagnosed based on thin-needle cytology and ten by biopsy. We reviewed standard protocols for diagnosing animal lymphoma, together with new methodologies, including molecular pathology. Diagnosis includes the phenotype of the tumour, its relationship to surrounding bodies, assessment of margins and tumour invasion and, in addition its immunohistochemical profile or molecular pathology may be included. To start the correct therapy, an early and accurate diagnosis is necessary.