Molecular markers of response and resistance to EGFR inhibitors in head and neck cancers (original) (raw)
2013, Frontiers in Bioscience
AI-generated Abstract
This review addresses the role of epidermal growth factor receptor (EGFR) in squamous cell carcinoma of the head and neck (SCCHN), highlighting its overexpression in the majority of SCCHN cases. A focus is placed on the therapeutic strategies targeting EGFR, including small molecules and monoclonal antibodies, and the molecular markers associated with response and resistance. Insights into overcoming therapeutic resistance and considering alternative receptor tyrosine kinases as potential targets for combination therapies are also presented.
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