1-(1 H -Indol-3-yl)ethanamine Derivatives as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors (original) (raw)

The emergence of multidrug-resistant (MDR) bacteria, particularly methicillin-resistant Staphylococcus aureus (MRSA), poses a significant global health threat. This study focuses on the development of 1-(1 H -indol-3-yl)ethanamine derivatives as potential inhibitors of the NorA efflux pump in S. aureus, which contributes to fluoroquinolone resistance. The research evaluates the efficacy of these compounds through cytotoxicity assays to determine their selective inhibition against normal and cancer cell lines.