Seizure and memory outcome following temporal lobe surgery: selective compared with nonselective approaches for hippocampal sclerosis (original) (raw)

HE syndrome of MTLE/HS is the most common medically refractory epilepsy syndrome in adolescents and adults seen in epilepsy surgery programs. 14,16 Excellent surgical results in terms of seizure control and psychosocial rehabilitation have proven that MTLE/HS is a surgically remediable disorder. 14,44 Note, however, that the increasing ability to visualize the sclerotic hippocampus on MR imaging 2,12,20,21 and the evolving knowledge about the pathogenetic bases of MTLE/HS have raised questions about the best surgical approach to treat patients with refractory seizures. Particularly, it has been questioned whether the epileptogenic zone comprises both neocortical and mesial temporal structures or whether the latter are sufficient to generate the recurrent seizures in this disorder.