Ongoing cumulative effects of single TMS pulses on corticospinal excitability: An intra- and inter-block investigation (original) (raw)

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015

Abstract

To evaluate the effects of several single TMS pulses, delivered at two different inter-trial intervals (ITIs), on corticospinal excitability. Twelve healthy volunteers participated in two experimental sessions, during which TMS pulses were delivered at random or at fixed ITIs. The TMS single pulse-induced modulation of corticospinal output (motor evoked potential amplitude - MEP) was evaluated on-line. Each session began with a baseline block, followed by 10 blocks, with 20 TMS pulses each. Intra- and inter-block effects were valuated using an ANOVA model, through nested random effect on subjects considering the subject-specific variability. The delivery of successive TMS pulses significantly changed both intra-block and inter-block cortical excitability, as demonstrated by an increase in the amplitude of MEPs (p<0.001) and supported through trend analyses, showing a perfect linear trend for inter-block levels (R(2)=1) and nearly linear trend for intra-block levels (R(2)=0.97). T...

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