Self-Assembled DNA-Based Structures for Nanoelectronics (original) (raw)
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Self-Assembled DNA Nanostructures and DNA Devices
Nanofabrication Handbook, 2012
This chapter overviews the past and current state of the emerging research area in the field of nanoscience that make use of synthetic DNA to self-assemble into DNA nanostructures and to make operational molecular-scale devices. Recently there have been a series of quite astonishing experimental results -which have taken the technology from a state of intriguing possibilities into demonstrated capabilities of quickly increasing scale and complexity. We discuss the design and demonstration of molecular-scale devices that make use of DNA nanostructures to achieve: molecular patterning, molecular computation, amplified sensing and nanoscale transport. We particularly emphasize molecular devices that make use of techniques that seem most promising, namely ones that are programmable (the tasks executed can be modified without entirely redesigning the nanostructure) and autonomous (executing steps with no external mediation after starting).
NanoBioTechnology, 2008
We discuss the basic inspiration underlying the drive towards using DNA molecules for nanotechnological applications, and focus on their potential use to develop novel nanoelectronic devices. We thus review the current level of understanding of the behavior of DNA polymers as conducting wires, based on experimental and theoretical investigations of the electronic properties, determined by the π-π superposition along the helical stack. First, the importance of immobilizing molecules onto inorganic substrates in view of technological applications is outlined: selected observations by suitable imaging techniques are commented. Then, the emphasis is shifted to investigations of the electronic structure: Disappointing evidences for negligible conductivity, from both theory and experiment, on double-stranded DNA molecules, are lately counterbalanced by clear-cut measurements of high currents in controlled experimental conditions that rely on avoiding non-specific molecule-substrate interactions and realizing electrode-molecule covalent binding. As a parallel effort, scientists are now tracing the route towards the exploration of tailored DNA derivatives that may exhibit enhanced conductivity. We illustrate few promising candidates and the first studies on such novel molecular wires.
Overview of New Structures for DNA-Based Nanofabrication and Computation
2000
Summary This paper presents an overview of recent experimental progress by the Duke DNA NanoTech Group in our efforts to utilize novel DNA nanostructures for computational self-assembly as well as for templates in the fabrication of functional nano-patterned materials. We have prototyped a new DNA tile type known as the 4x4 (a cross-like structure composed of four four-arm junctions) upon
Synthetic Metals, 2003
DNA is one of the most promising molecules as the scaffold for molecular nanotechnology and nanoelectronics. For realizing the molecular devices constructed with DNA, three kinds of function is required such as (1) circuit and control of the conductivity, (2) switching and (3) storage. We have found that the electrical conducting properties of the DNA networks are strongly depended on the doping condition. Photoswitching (current enhancement with shining the light) and magnetoresistance effect are observed in the dye-modified DNA and Co ions doped DNA, respectively. Furthermore, DNA network pattern can be patterned on the Si/SiO 2 surface. These results have significant implications for the application of DNA in electronic devices and in DNA-based electrochemical biosensors.
Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization
Nanomaterials
Bottom-up fabrication using DNA is a promising approach for the creation of nanoarchitectures. Accordingly, nanomaterials with specific electronic, photonic, or other functions are precisely and programmably positioned on DNA nanostructures from a disordered collection of smaller parts. These self-assembled structures offer significant potential in many domains such as sensing, drug delivery, and electronic device manufacturing. This review describes recent progress in organizing nanoscale morphologies of metals, semiconductors, and carbon nanotubes using DNA templates. We describe common substrates, DNA templates, seeding, plating, nanomaterial placement, and methods for structural and electrical characterization. Finally, our outlook for DNA-enabled bottom-up nanofabrication of materials is presented.
Self-assembled DNA Structures for Nanoconstruction
2004
In recent years, a number of research groups have begun developing nanofabrication methods based on DNA self-assembly. Here we review our recent experimental progress to utilize novel DNA nanostructures for self-assembly as well as for templates in the fabrication of functional nano-patterned materials. We have prototyped a new DNA nanostructure known as a cross structure. This nanostructure has a 4-fold
DNA-templated assembly of nanoscale architectures for next-generation electronic devices
Faraday Discussions, 2006
We report the assembly and structural characterization of a Y-shaped DNA template incorporating a central biotin moiety. We also report that this template may be used to assemble nanoscale architectures, which demonstrate the potential of this and related approaches to the fabrication of next-generation electronic devices. Of particular significance is the finding that it is possible to selectively metallize the above DNA template to obtain a three-electrode configuration. Also of particular significance is the finding that a biotin modified nanoparticle will recognize and bind selectively the central biotin moiety of the same template, once functionalized by the protein streptavidin.
Toward electronically-functional, self-assembling DNA nanostructures
Journal of self-assembly and molecular electronics, 2018
Recent work has demonstrated that DNA, ordinarily considered a weak conductor, can be functionalized to carry electronic charge by site-specific incorporation of single silver ions inside the double helix via the non-canonical pairing of mismatched cytosines through Ag + coordination: (dC:Ag + :dC) [1,2]. Through the alteration of sequence composition and cation availability, a variety of nanowires can be synthesized with tuneable length, ion distribution, and uniformity. These wires are more thermostable than Watson-Crick DNA, can shield intercalated Ag + from aqueous solvents, and are able to form in the absence of cluster contamination. We use computational sequence design algorithms to introduce nonlinear geometry to these nanowires, with the goal of creating self-assembling DNA nanostructures that may have potential for neural architectures from electrically-functional oligonucleotide components.
Electronic nanostructures templated on self-assembled DNA scaffolds
Nanotechnology, 2004
We report on the self-assembly of one-and two-dimensional DNA scaffolds, which serve as templates for the targeted deposition of ordered nanoparticles and molecular arrays. The DNA nanostructures are easy to reprogram, and we demonstrate two distinct conformations: sheets and tubes. The DNA tubes and individual DNA molecules are metallized in solution to produce ultra-thin metal wires.