Long-term regulation of neuronal calcium current by prolonged changes of membrane potential (original) (raw)

The Journal of Neuroscience : The Official Journal of the Society for Neuroscience

Abstract

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This study investigates the long-term modulation of neuronal calcium currents in rat myenteric neurons subjected to prolonged depolarization. Findings indicate that chronic depolarization leads to a significant decrease in the density of calcium channel currents, with a faster reduction observed in decaying components compared to sustained ones. Recovery of these currents upon reversion to control conditions reveals distinct regulatory mechanisms for the two current components, emphasizing the critical role of calcium channels in neuronal activity adaptation and synaptic strength modulation.

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