Mucinous Cystic Tumor of the Pancreas with Ovarian-like Mesenchymal Stroma in a Male Patient (original) (raw)
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Mucinous cystic neoplasm of the pancreas in a male patient
Rare tumors, 2011
Mucinous cystic neoplasms (MCNs) make up a morphologic family of similar appearing tumors arising in the ovary and various extraovarian organs such as pancreas, hepatobiliary tract and mesentery. MCNs of the pancreas occur almost exclusively in women. Here, we report a rare case of MCN in a male patient. A 39-year-old man was admitted to our hospital with the chief complaint of back pain. Abdominal computed tomography revealed a multilocular cyctic mass 6.3 cm in diameter in the pancreatic tail. In addition, the outer wall and septae with calcification were demonstrated in the cystic lesion. On magnetic resonance imaging , the cystic fluid had low intensity on T1-weighted imaging and high intensity on T2-weighted imaging. Endoscopic retrograde cholangio-pancreatography (ERCP) showed neither communication between the cystic lesion and the main pancreatic duct nor encasement of the main pancreatic duct. Endoscopic ultrasonography revealed neither solid component nor thickness of the s...
The American Journal of Surgical Pathology, 1999
Mucinous cystic naopIasms (MCNs) of the p c r e a s are uncommon tumors. The classifntion and biologic potential of these neoplasms n m a h the subject of controversy. Attempts to classify t h~ tumors in a sirnilat manner to ovarian MCNs remains controversial, as even ~t o l o g i d y bmignappe.amg pmcrealic MCNs metastasize and art IethaI. One hundred cases of MCNs were identXed in the files of the trine Pathology Tumor R c w of the Armed P m s Institute of PathoIogy from the YCBF~ 1979 to 1993. The pathologic features, including hematoxylin and Basin s w n g , bistochemishy, i m m u 1 1~h e m i s k y (XHC), ocll cycle analysis, and K-ms oncogene detamhation were review&. These finwere correlated with the clinical follow-up obtained in all cases. There were 130 women, aged 2 M 5 years (mean age at the outset, 44.6 y w ) . Tbt m t s had vague abdominal pain, fullness, or abdominal masses. More than 95% of the tumors were in the m c tail or body and were p d o m h n t l y m u l t i l~. The tumors xanged in size from 1.5 to 36 cm in greatest dimension, with the average tumor measuring >I0 cm. A specttum of hbtomorphologic changes were present within the same case and from case to we. A single layer of blandappearing, sialomucin-producing columnar epithelium Iining the cyst wall wouId abruptly change to a complex papillary architecture, with and without cytologic atypia, and with and without s t c o d invasion. Ovarian-type smma was a c b teristic and requisite f e w . Focal sclerotic hyalhhtion of the siroma was noted. This ovarian-type smma reacted with *nth, smooth muscle actin, progesterone, w cstmgen re-From the -t of E d m h e and OtorJholaryn@c-Head & Neck Pathology &D.RT., C F . k , CS-H), the -t ofC?IlW Pathology, Mole& Division (RMP.). and the Deparment of Cellular Pathology, Division of Quantitative Pathology (R.C.B.), ArmGd Forces Mtute of Pathology, Washington, DC. Address ~~c e and reprint quests to Dr. Lester D.R Thompson, Dcpammt of Bndocrint and OtorhinohyngmBd & Nezk Pathology, BuMmg 54, Room GO661 1, hmd Forcss Institute of Pathology, 6825 16th Sh-cct NW, Washugmi, DC 2M066000, U.S.A. h n t e d at the 86th Annual Metting of tbe United Stares d Can a a n Academy of PaihoIogy, Orlando, FIoria March 1-8, 1997.
Mucinous cystic neoplasm of the pancreas: a case report
Chirurgia italiana
Cystic neoplasms of the pancreas account for only a small percentage of pancreatic tumours. They include mucinous cystic tumours, which have a higher incidence in females in their forties or fifties. Cystic neoplasms of the pancreas can present in a benign, borderline or malignant form. These tumours have a natural evolution from a benign (mucinous cystadenoma) to a malignant form (cystadenocarcinoma). It is not always easy to diagnose cystic tumours, including mucinous cystic tumours of the pancreas, and the final diagnosis is often reached only after the surgical procedure, which is the gold standard treatment of this disease. We present the case of a 56-year-old woman affected by a mucinous cystic tumour of the body-tail of the pancreas, who underwent distal splenopancreasectomy. She was discharged on postoperative day 12. After an 18-month followup, she is in good general condition and disease-free.
International Journal of Surgery Case Reports, 2019
INTRODUCTION: Mucinous cystic neoplasms (MCN) are rare premalignant neoplasms of the pancreas that are typically found as single lesions in the pancreatic body and tail of women in the fifth and sixth decade of life, do not communicate with the pancreatic ductal system and are characterized by mucin-producing epithelium supported by ovarian-type stroma. PRESENTATION OF CASE: We present here a case of diffuse pancreatic involvement by MCN in a 64year-old woman with chronic pancreatitis. Pre-operative suspicion for MCN was low due to the multicentric nature of the lesions and imaging/biochemical fluid analysis demonstrating connection with the pancreatic ductal architecture. The patient underwent total pancreatectomy with pathology showing multiple cysts lined by flat epithelium with focal ovarian-type stroma, consistent with low-grade MCN. DISCUSSION: The presence of ovarian stroma on histological analysis is one of the defining characteristics of MCNs per WHO guidelines, and is mandatory for its diagnosis. Only one case of diffuse MCN has been previously described in the literature; however, in this case the authors were not able to reach a definitive histological diagnosis based on WHO criteria. CONCLUSION: To our knowledge, this is the first report of diffuse histology-proven MCN of the pancreas.
The American Journal of Surgical Pathology, 1999
Mucinous cystic naopIasms (MCNs) of the p c r e a s are uncommon tumors. The classifntion and biologic potential of these neoplasms n m a h the subject of controversy. Attempts to classify t h~ tumors in a sirnilat manner to ovarian MCNs remains controversial, as even ~t o l o g i d y bmignappe.amg pmcrealic MCNs metastasize and art IethaI. One hundred cases of MCNs were identXed in the files of the trine Pathology Tumor R c w of the Armed P m s Institute of PathoIogy from the YCBF~ 1979 to 1993. The pathologic features, including hematoxylin and Basin s w n g , bistochemishy, i m m u 1 1~h e m i s k y (XHC), ocll cycle analysis, and K-ms oncogene detamhation were review&. These finwere correlated with the clinical follow-up obtained in all cases. There were 130 women, aged 2 M 5 years (mean age at the outset, 44.6 y w ) . Tbt m t s had vague abdominal pain, fullness, or abdominal masses. More than 95% of the tumors were in the m c tail or body and were p d o m h n t l y m u l t i l~. The tumors xanged in size from 1.5 to 36 cm in greatest dimension, with the average tumor measuring >I0 cm. A specttum of hbtomorphologic changes were present within the same case and from case to we. A single layer of blandappearing, sialomucin-producing columnar epithelium Iining the cyst wall wouId abruptly change to a complex papillary architecture, with and without cytologic atypia, and with and without s t c o d invasion. Ovarian-type smma was a c b teristic and requisite f e w . Focal sclerotic hyalhhtion of the siroma was noted. This ovarian-type smma reacted with *nth, smooth muscle actin, progesterone, w cstmgen re-From the -t of E d m h e and OtorJholaryn@c-Head & Neck Pathology &D.RT., C F . k , CS-H), the -t ofC?IlW Pathology, Mole& Division (RMP.). and the Deparment of Cellular Pathology, Division of Quantitative Pathology (R.C.B.), ArmGd Forces Mtute of Pathology, Washington, DC. Address ~~c e and reprint quests to Dr. Lester D.R Thompson, Dcpammt of Bndocrint and OtorhinohyngmBd & Nezk Pathology, BuMmg 54, Room GO661 1, hmd Forcss Institute of Pathology, 6825 16th Sh-cct NW, Washugmi, DC 2M066000, U.S.A. h n t e d at the 86th Annual Metting of tbe United Stares d Can a a n Academy of PaihoIogy, Orlando, FIoria March 1-8, 1997.
Mucinous Cystic Neoplasm of Pancreas in a Male Patient: A Case Report and Review of the Literature
Journal of the Louisiana State Medical Society, 2014
Mucinous cystic neoplasms (MCNs) are among the most common primary cystic neoplasms of pancreas. These lesions usually occur in body and tail of the pancreas and are characterized by the presence of ovarian type stroma in the pathological evaluation. Mucinous cystic neoplasms have significant malignant potential; therefore, their diagnosis and resection is of utmost importance. Mucinous cystic neoplasms typically occur in women. Only a few cases have been previously reported in male patients. In this case report, we present a 48-year-old man who was referred to our center due to an incidentally found cystic lesion in the tail of the pancreas that was increasing in size in serial evaluation. The patient underwent open distal pancreatectomy. The pathology showed mucinous cystic neoplasm with characteristic ovarian type stroma and positive staining for estrogen and progesterone receptors. This case report shows that mucinous cystic neoplasms can occur in men and should be considered in differential diagnosis of cystic pancreatic lesions in this population.
Diagnosis and Management of Pancreatic Mucinous Cystadenoma
Journal of Surgical Sciences, 2015
Pancreatic mucinous cystadenomas (MCAs) are considered to be benign tumors with a high risk of malignant progression. The pancreatic mucinous cystadenoma is considered to be a rare condition that may lead to pancreatic cancer when not surgically resected. MCAs represent 9.7% of all neoplastic pancreatic cysts. The male:female ratio of MCAs is 1:10. The condition appears mostly in women, mean age in the 5th decade. The cyst is restricted by a fibrous capsule of variable consistency and has usually no communication with the pancreatic ductal system. The MCAs are located mostly in the body or tail of the pancreas. The MCAs located in the head of the pancreas are more likely to be malignant. Complete surgical resection is the recommended therapeutic option. We present a case of a 59-year-old female patient admitted in the Departemt of Surgery and Liver Transplatation of Fundeni Clinical Institute for recurrent episodes of acute pancreatitis. After a thorough investigation was performed, the CT-examination showed a pancreatic mass, located in the tail, measuring 30/40mm. Because the CT aspect was specific for a cystic-like lesion, surgery was recommended. The patient underwent a laparoscopic caudal splenopancreatectomy with a favorable postoperative evolution. The particularity of the case comes from the patient's clinical presentation, with recurrent acute pancreatitis and the imagistic aspect (ultrasound and CT) that initially suggested a pseudocystic-like lesion, but the elevated CA 15-3 and further elaborated examinations indicated a possible malignant lesion.
Pancreatic mucinous cystic neoplasm in a male patient
JOP : Journal of the pancreas, 2012
Mucinous cystic neoplasm (MCN) of the pancreas usually affects female patients and is characterized by an ovarian-type stroma. From literature review, only 9 cases of MCNs have been reported in male patients. We describe the 10th case of a MCN in a 65-year-old male patient who underwent a distal pancreatectomy with spleen resection and standard lymphadenectomy. MCN may rarely regard male patients, probably for embryological abnormalities.
Mucinous cystic neoplasm of pancreas a case report
International Surgery Journal
Mucinous cystic neoplasm of pancreas are relatively rare >95% occur in the body and tail of pancreas. Majority occur in young and middle aged female containing ovarian type subepithelial stroma. These tumors are either premalignant (MCN with low grade dysplasia) or (MCN with high grade dysplasia) or invasive carcinoma. Differential diagnosis includes pancreatic pseudocyst and pancreatic hydatid cyst. Investigations include ultrasonography (USG), Magnetic resonance imaging (MRI), Contrast enhanced computed tomography (CECT) supplemented by endoscopic USG with cyst fluid aspiration.
Mucinous Cytadenoma of the Pancreas: A Case Report with Review of the Literature
Journal of Surgery & Anesthesia Research
Mucinous cystadenomas are a rare entity of cystic lesions of the pancreas, often discovered incidentally and posing a preoperative diagnostic challenge. Women are more often affected than men and these lesions are often asymptomatic, discovered by imaging and biological means. Benign pancreatic mucinous cystadenomas have a very high cure rate with a reduced rate of degeneration. Simple excision of benign pancreatic cysts is considered safe and effective with a very low recurrence rate.