Incorporation of chemical functionalities in the framework of mesoporous silica (original) (raw)
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Applications of mesoporous silica nanomaterial: an over view
Nanomaterials are physical substances with at least one characteristic dimension between 1-100nm. Porous inorganic material show good stability under extreme physical and chemical conditions. Interestingly, both of these characteristics are present in Mesoporous Silica Nano (MSN) materials. MSN materials have a highly regular porous structure with uniform pore size, vast surface areas and superior thermal stability. Hence MSN is suitable for a variety of applications in the field of drug delivery, biosensors, molecular separations, catalysis and separation efficient catalyst for the degradation of plastics. In this overview, we present various synthesis methods of MSN and recent research developments of a series of surface-functionalized mesoporous silica nano materials. We have also discussed about the applications of MSN in various fields. Keywords : Mesoporous silica nanomaterial, Drug delivery, Biosensors, Catalyst.
Stepwise functionalization of mesoporous crystalline silica materials
Microporous and Mesoporous Materials, 1998
Novel properties have been achieved in mesoporous crystalline silica materials by organic functionalization. In this study, localized functionalization and bifunctionalization of silica MCM-41 was attempted through the stepwise postsynthesis silylation. When MCM-41 was treated with various silylating agents for 6 hours before template removal, change in pore size only was observed without any change in surface area and pore volume. MCM-41 was difunctionalized with both decyl groups on edges of pores and methyl groups on inner surfaces of pores. Capillary condensation of water took place at higher relative pressure in MCM-41 with decyl groups on edges than in unsilylated MCM-41, whereas hydrophobic property was observed in MCM-41 which were difunctionalized with decyl groups on edges of pores and with methyl groups on inner surfaces of pores. This study shows that the manipulation of pore size and functionality with/without any change in surface area and pore volume and the combination of two different functionalities could be achieved in MCM-41 through the stepwise functionalization.
Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts
Applied Sciences
The application of silica mesoporous structures in drug delivery and the removal of pollutants and organic compounds through catalytic reactions is increasing due to their unique characteristics, including high loading capacities, tunable pores, large surface areas, sustainability, and so on. This review focuses on very well-studied class of different construction mesoporous silica nano(particles), such as MCM-41, SBA-15, and SBA-16. We discuss the essential parameters involved in the synthesis of these materials with providing a diverse set of examples. In addition, the recent advances in silica mesoporous structures for drug delivery and catalytic applications are presented to fill the existing gap in the literature with providing some promising examples on this topic for the scientists in both industry and academia active in the field. Regarding the catalytic applications, mesoporous silica particles have shown some promises to remove the organic pollutants and to synthesize fina...
State of the Art Review on Emerging Applications of Mesoporous Silica
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The recent advances in the drug delivery system using a variety of technological platforms have resulted in innovation in the attitude towards diagnosis and therapeutics alike in the present times. Mesoporous Silica possesses favourable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica makes possible the effective loading of drugs and their subsequent release in a controlled manner at the target site. The properties like pore size, high drug loading, and porosity as well as the surface properties of Mesoporous silica make them a suitable platform for many drug delivery applications. This review focuses on the applications and the advances made in the mesoporous silica to broaden the spectrum of its use especially in the field of medicine. The Mesoporous Silica carrier has proved its use in the field of biosensing, controlled and targeted drug release, gene delivery, water treatment, solubility and bioavailability enhancement and ...
Molecules, 2021
Mesoporous silica nanostructures (MSNs) attract high interest due to their unique and tunable physical chemical features, including high specific surface area and large pore volume, that hold a great potential in a variety of fields, i.e., adsorption, catalysis, and biomedicine. An essential feature for biomedical application of MSNs is limiting MSN size in the sub-micrometer regime to control uptake and cell viability. However, careful size tuning in such a regime remains still challenging. We aim to tackling this issue by developing two synthetic procedures for MSN size modulation, performed in homogenous aqueous/ethanol solution or two-phase aqueous/ethyl acetate system. Both approaches make use of tetraethyl orthosilicate as precursor, in the presence of cetyltrimethylammonium bromide, as structure-directing agent, and NaOH, as base-catalyst. NaOH catalyzed syntheses usually require high temperature (>80 °C) and large reaction medium volume to trigger MSN formation and limit ...
Recent Trends in Morphology-Controlled Synthesis and Application of Mesoporous Silica Nanoparticles
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The outstanding journey towards the investigation of mesoporous materials commences with the discovery of high surface area porous silica materials, named MCM-41 (Mobil Composition of Matter-41) according to the inventors’ name Mobile scientists in the United States. Based on a self-assembled supramolecular templating mechanism, the synthesis of mesoporous silica has extended to wide varieties of silica categories along with versatile applications of all these types in many fields. These silica families have some extraordinary structural features, like highly tunable nanoscale sized pore diameter, good Brunauer–Emmett–Teller (BET) surface areas, good flexibility to accommodate different organic and inorganic functional groups, metals etc., onto their surface. As a consequence, thousands of scientists and researchers throughout the world have reported numerous silica materials in the form of published articles, communication, reviews, etc. Beside this, attention is also given to the ...