Zinc ions as cytochrome c oxidase inhibitors: two sites of action (original) (raw)

2005, Biochemistry (Moscow)

Both mitochondrial and bacterial respiratory chains supply the cell with energy due to the conversion of ener gy released from the oxidation of substrates into trans membrane proton gradient across the coupling mem brane. The electron transfer complexes of the respiratory chain, such as NADH:ubiquinone reductase (complex I), ubiquinol:cytochrome c reductase (complex III, or the complex of cytochromes bc 1 ), and cytochrome c oxidase (COX, complex IV) are the coupling membrane bound multisubunit proteins, which act as redox driven proton pumps translocating protons from the inside of mito chondrion to the outside [1 3].

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