Evaluation of MENT on primary cell cultures from benign prostatic hyperplasia and prostate carcinoma (original) (raw)

2009, International Journal of Andrology

AI-generated Abstract

The study evaluates the effects of 7-alpha-Methyl-19-Nortestosterone (MENT), a synthetic androgen, on primary cell cultures derived from benign prostatic hyperplasia (BPH) and prostate carcinoma (CaP). Findings indicate that MENT enhances prostate-specific antigen (PSA) secretion and proliferation in both BPH and CaP cultures, with effects ranging between those of testosterone (T) and dihydrotestosterone (DHT). Additionally, MENT's action is resistant to the enzyme 5-alpha reductase, suggesting its potential for low impact regarding prostate pathology during androgen replacement therapy.