In vitro evaluation of different aqueous extracts of Senna alata leaves for antibacterial activity (original) (raw)
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Gastric disorders like hyperacidity and ulcers are a common clinical entity. A rational therapy for gastric ulcers still remains elusive and search for safer potential drugs is being carried out. The present comparative experimental study was planned to see the efficacy of two Ayurvedic formulations i.e. Narikela Khanda (Cocus nucifera candy) and Narikela Khanda granules by using swimming stress induced ulcers and hypothermia in albino rats. Wister strain albino rats of either sex were divided into three groups, each group consists of six animals. Here group A received Narikela Khanda suspension, while group B received Narikela Khanda granules suspension and group C received dose of tap water which served as stress control group. Narikela Khanda and Narikela Khanda granules were prepared in house laboratory of the department. Wister strain albino rats of either sex weighing between 150-250g were selected for the study. Effects of both the formulations were assessed on different para...
Combined Effects of Medicinal Plants on Induced Upper Gastrointestinal Tract Injury in Wistar Rats
Ethiopian Journal of Health Sciences, 2016
BACKGROUND: Herbal medicines are now recently used as treatment options. This study was conducted to determine the effect of the combination therapy of medicinal herbs in the treatment of induced gastrointestinal injury among albino wistar rats. METHODS: A total of 60 Albino Wistar rats of both sexes weighing between 130g-150g were used. The control groups which consisted of negative control groups received 1ml of normal saline while the positive control group was given 20mg/kg of indomethacin and sacrificed after 6 hours. Those in the test group were given 20mg/kg of indomethacin, treated in different doses of single and combined extracts of Allium sativum, Brassica oleracea and Aloe barbadensis at 100mg/kg, 200mg/kg and 300mg/kg body weights, twice daily for 8 days and sacrificed. RESULTS: There was no visible sign of ulceration or perforation observed on the stomach and duodenum when compared with the control. The combination of all three plant extracts at different concentrations ranging from 100-300mg/kg cleared all visible ulcers and perforations on the stomach of wistar rats. Similarly, all ulcers in the duodenum of indomethacin induced wistar rats were cleared by the combination of the three extracts. The sections of rat stomach and duodenum given 100mg/kg herbal cocktail and indomethacin showed normal mucosa. CONCLUSIONS: A mixture of the three herbs at 300mg/kg was better in healing gastric and duodenal ulcers. The mixture of the three plants extracts exhibit good anti-ulcer activity that warrants further studies.
Anti-Ulcerogenic Effect of Some Indian Medicinal Plants on Mucosal Lesion in Rats
The antiulcer activity of the poly herbal formulation (composed of the leaf extracts from Lantana camara, Annona muricata, Kalanchoe pinnata) was evaluated in necrotizing agents induced ulcer model in rats. The extract at dose of 1000mg/kg produced significant inhibition of gastric lesion induced by above mentioned method. The extract reduced ulcerative lesion, gastric volume, free and total acidity and pH of gastric juice in the model. The result obtained suggesting that extract possesses significant anti-ulcer activity.
AN REVIEW ARTICLE ON THE ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANTS
Peptic ulcer is one of the most common gastrointestinal diseases. The exact causes of peptic ulcer disease are not known but it may be result from an imbalance between acid-pepsin secretion and mucosal defence factors. Peptic ulcer disease occurs mainly due to consumption of NSAIDs, infection by H. pylori, stress, or due to a pathological condition such as Zollinger –Ellison Syndrome. Nature provides a number of medicines and perhaps all solutions for human illnesses. So far, nature supplies many clinically useful drugs. Ulcer is a major increasing health problem. Nowadays, there are several synthetic medications available for the treatment of peptic ulcers, but these drugs are expensive and are likely to produce more side effects than herbal drugs. Certain antiulcer drugs such as proton pump inhibitors and H2 receptor antagonists are used to treat peptic ulcers. However, these drugs have shown disease relapse, side effects, and even drug interactions. Numerous medicinal plants have anti-ulcer activity and are useful in the treatment of peptic ulcers. The aim of this review is to find out more about the anti-ulcer properties of herbal medicines. The present article reviews the antiulcerogenic and ulcer healing property of Ocimum sanctum, Allophylus serratus, Desmodium gagenticum, Azadirachta indica, Hemidesmus racemosus, Asparagus racemosus, and Musa sapientum. We have brought to light some of the important plants reported for their anti-ulcer and ulcer healing properties. Ayurvedic knowledge supported by modern science is necessary to isolate, characterize and normalize the active components of herbal sources for antiulcerative activity. KEYWORDS: Antiulcer activity, Ethanolic extract, Aspirin-induced ulcer model, NSAIDs.
2013
Distress is one of the most dangerous epidemics having potential to cause severe somatic and psychiatric disorders. Rasayana (rejuvenation therapy) drugs in Ayurveda can be an answer to prevent stress induced disorders. Rasayana powder, an Ayurvedic formulation, is used for health promoting and anti-ageing benefits. The present study was conducted to evaluate the adaptogenic and antiulcer potency of Rasayana Ghana tablet (RGT) in experimental animals in reverse pharmacological approach. Charles Foster strain albino rats of either sex were divided into five groups and treated as Water control, Stress control, Ghee and Honey treated (Vehicle control), RGT with vehicle control and Standard control. All the animals were subjected to pharmacological protocol of forced swimming stress. RGT was administered along with vehicle in the dose of 180 mg/kg orally for 7 consecutive days before subjecting to stress. The adaptogenic and anti-ulcer activities were assessed on the basis of changes in rectal temperature, body weight, ulcer index, haematological parameters and antioxidant activities. In forced swimming hypothermia, pre-treatment with RGT caused significant attenuation of rectal temperature when compared with both stress control group. The RGT showed significant attenuation on stress induced gastric ulcers by quenching free radicals. Further it significantly prevented stress induced leucopenia. Thus, it can be concluded that RGT along with ghee and honey as vehicle possess anti-stress and adaptogenic activity.
Indian journal of experimental biology, 2004
Gastric ulcers were induced in normal/NIDDM rats by various physical (2 hr cold restraint stress and 4 hr pylorus ligation) and chemical agents (ethanol, 1 ml/200 g, oral, 1 hr before; aspirin, 200 mg/kg, oral, 4 hr) and duodenal ulcers were induced by cysteamine (40 mg/200 g). Ulcer healing activity was studied in gastric ulcers induced by acetic acid (50%) and HCI (0.6 M). The result indicated that in both, normal and NIDDM rats, B. monniera extract (BME, 20-100 mg/kg) did not show any significant effect on blood glucose level, while A. indica (AIE, 250-1000 mg/kg) significantly decreased it. However, both BME (50 mg/kg) and AIE (500 mg/kg) showed significant anti-ulcer and ulcer-healing activities in normal and NIDDM rats. Further, the present results also indicated that the ulcer protective effects of BME was more pronounced in non-diabetic, while that of AIE was more in NIDDM rats. The anti-ulcer and ulcer-healing activities of BME and AIE may be due to their effects on various...
Anti-ulcer Activity of Some Selected Medicinal Plants: A review
2018
A peptic ulcer is an ulcer of one of those areas of the gastrointestinal tract that are usually acidic. Peptic ulcer formation occurred due to the acid of excess, peptic activity in gastric juice as well as a breakdown in mucosal defenses. Some of anti-ulcer medicines such as proton pump inhibitors and H2 receptor antagonists are used for peptic ulcer treatment. However, these drugs have shown disease relapse, side effects, and even drug interactions. Many medicinal plants exhibit anti-ulcer activity and found useful in the treatment of peptic ulcer. The purpose of this review is to know more about the anti-ulcer properties of the medicinal plants. Serjania marginata (HESM) leaves, thymol obtained from Thymus, Origanum and Cuphea aequipetala infusion (CAI) In this review there is information about some kinds of plants which are very useful in treating peptic ulcer disease such as hydroalcoholic extract obtained from S. marginata (HESM) leaves, thymol obtained from Thymus, Origanum a...
A Study of Various Medicinal Plants used in Ulcer Treatment: A Review
Journal for Research in Applied Sciences and Biotechnology, 2023
Many people suffer from ulcer, a disorder of the digestive tract. Simply put, it's an inflamed break in the skin or the mucus membrane lining the digestive tract. Whenever there is a change in the equilibrium, such as increased aggression or decreased mucosal resistance, ulceration develops. Reasons for this could include drug use, poor diet, stress, and other similar factors. Peptic ulcers are a general term for any type of stomach or duodenal ulcer. To develop, peptic ulcers need mucosal defences to be compromised in addition to gastric juice acid and peptic activity. Ulcers can be treated with a variety of synthetic medications. However, compared to herbal remedies, these drugs are more costly and more likely to cause side effects. According to the research, many different ayurvedic doctors and traditional medicine practitioners use different medicinal plants and polyherbal formulations to treat ulcers. Peptic ulcer disease treatment should focus on symptom alleviation, ulcer healing, and preventing recurrence. In this article, we'll take a look at some medicinal plants that have been studied for their potential use in peptic ulcer treatment and prevention, both in ayurveda and Western medicine.
Therapeutic potential of indigenous medicinal plants against gastric ulcer
Annals of phytomedicine, 2022
Ulcers are a frequent gastrointestinal condition that affects many different sections of the body. The intestinal mucosal layer that lines the gastrointestinal tract can be disrupted or breached by ulcers. Peptic ulceration is now known to be caused by an imbalance of aggressive and defensive elements. There are already a plethora of synthetic pharmaceuticals available to treat peptic ulcers and their consequences, but these therapies are either excessively expensive or have a variety of negative effects. Peptic ulcers are currently being treated using a variety of medicinal herbs and polyherbal formulations. In this review article, we look at various medicinal plants that can be utilized in both ayurvedic and western medicine to heal peptic ulcers and reduce their consequences. Apart from their antiulcer activity, the medicinal plants possesses tremendous therapeutic potentials like Asparagus racemosus L. is known to be quiet effective in the treatment of problems associated with female reproductive system, Solanum nigrum L. cures psoriasis and ringworm, inflammatory disorders, menstrual cramps. Carica papaya L. known to possess antithrombocytopaenic, immunomodulatory and anti-inflammatory potentials.
Anti-Peptic Ulcer Activity of Muktashukti Bhasma
Background: Pearl oyster is found at Atlantic and Indian Ocean coasts. Its ash or paste is used in ancient Ayurvedic medicine to manage various gastric disorders. Muktashukti Bhasma (Pearl Oyster Shell) is the calcinated shell of pearl oyster and has calcium, magnesium and iron. It is well known for its antacid and digestive properties. We carried out this study to investigate anti-peptic ulcer activity of Muktashukti Bhasma (MSB). Methods: Two hundred and thirty-eight inbred Albino rats of either sex were divided into 7 groups. Group-I (n=10) was control group, it was kept on distilled water. Suspension of Muktasukti Bhasma (MSB) was administered orally 100 mg/kg body wt. in group-II (n=6), 300 mg/kg body wt. in Group-III (n=6), and 1,000 mg/kg body wt. in Group-IV (n=6). In rest 3 groups (in all n=6) Ranitidine was administered subcutaneously at 0.5 mg/kg body wt. in Group-V, 2 mg/kg in Group-VI, and 5 mg/kg in Group-VII. All the Rats were sacrificed at the end of 19 hours after operation for pyloric ligation and gastric secretions were analyzed for pH, free acidity, and pepsin activity. Result: Muktashukti Bhasma caused reduction in ulcer score and ulcer index with all the doses. MSB caused significant reduction (p<0.001) in free and total acidity, and acid output only at 300 and 1,000 mg/kg dose. MSB and Ranitidine caused decrease in peptic activity at all dose levels. MSB also raised pH. Conclusion: Muktashukti Bhasma shows variable reduction in free and total acidity, acid output and peptic activity.