Defective STAT signaling by the leptin receptor in diabetic mice (original) (raw)
Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
Olga Charlat
Cell, 1996
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Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism
Tammy Barnes
Molecular Metabolism, 2020
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Critical role of STAT3 in leptin's metabolic actions
Alessandro Pocai
Cell Metabolism, 2006
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Leptin activates Stat3, Stat1 and AP-1 in mouse adipose tissue
Paola Maroni
Molecular and Cellular Endocrinology, 2000
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Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
Susanne Klaus
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001
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Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice
Allah Nawaz
Diabetology International, 2015
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Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
Dominique Pierroz
Journal of Clinical Investigation, 2000
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Essential Role of STAT3 in Body Weight and Glucose Homeostasis
Orhan Öz
Molecular and Cellular Biology, 2004
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A complex interaction pattern of CIS and SOCS2 with the leptin receptor
Lennart Zabeau
Journal of Cell Science, 2006
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The Long Form of the Leptin Receptor Regulates STAT5 and Ribosomal Protein S6 via Alternate Mechanisms
Diane Fingar
Journal of Biological Chemistry, 2007
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Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women
Francis Vasseur
Biochemical and Biophysical Research Communications, 2006
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Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms
bob cheng
Nature Medicine, 2008
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Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity
Cyril Couturier
2007
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Metabolic characterization of a mouse deficient in all known leptin receptor isoforms
Bruno Conti
Cellular and molecular …, 2010
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Abnormal regulation of the leptin gene in the pathogenesis of obesity
Eileen Connolly
Proceedings of the National Academy of Sciences, 1998
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Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets
alejandro gonzalez
Diabetologia, 2011
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Functional Potentiation of Leptin-Signal Transducer and Activator of Transcription 3 Signaling by the Androgen Receptor
Wuqiang Fan
Endocrinology, 2008
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Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor
H. Vidal
International Journal of Obesity, 2002
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Unsilencing of native leptin receptors (LepR) in hypothalamic SF1 neurons does not rescue obese phenotype in LepR-deficient mice
erika Tarasco
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
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Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity
Gwen Childs
Endocrinology, 2012
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Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor
Zhiying Li, Giovanni Ceccarini
Molecular metabolism, 2013
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Quantitative Expression Analysis of Genes Regulated by Both Obesity and Leptin Reveals a Regulatory Loop between Leptin and Pituitary-derived ACTH
Mark Renz
Journal of Biological Chemistry, 2000
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Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition
Frédéric Preitner
Journal of Clinical Investigation, 1997
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Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
Nicholas Morton
Diabetes, 1997
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Leptin signalling in pancreatic islets and clonal insulin-secreting cells
Valur Emilsson
Journal of Molecular Endocrinology, 1999
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Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
Hong Fei
Proceedings of the National Academy of Sciences, 1997
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Responses of lean and obese Zucker rats to centrally administered leptin
William Flatt, Diane Hartzell, Roy Martin, Tianlun Wang
Physiology & Behavior, 1998
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Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity
Scott Commins
American Journal of Physiology-endocrinology and Metabolism, 2000
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Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity
Jose Donato, carol elias, Julio toledo
Molecular Metabolism, 2014
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