Teaching NeuroImages: Marked reduced apparent diffusion coefficient in acute multiple sclerosis lesion (original) (raw)

A 24-year-old woman with acute neurological symptoms underwent brain MRI, revealing a significant decline in the apparent diffusion coefficient (ADC) in a demyelinating lesion consistent with multiple sclerosis. The ADC dropped approximately 70% compared to the contralateral white matter, highlighting a notable distinction from previous reports of lesser declines in ADC associated with acute demyelinating lesions, thereby indicating that ADC reductions in multiple sclerosis can resemble those observed in acute brain infarction.