Increase in maternal placental growth hormone during pregnancy and disappearance during parturition in normal and growth hormone-deficient pregnancies (original) (raw)

Abstract

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This research explores the dynamics of maternal placental growth hormone (GH) during normal pregnancy and its clearance during parturition. A longitudinal study of 17 healthy pregnant women revealed a significant increase in placental GH levels throughout gestation, with measurable levels as early as week 8. In a case of isolated pituitary GH deficiency, placental GH levels rose comparably to controls despite recombinant GH treatment. The half-life of placental GH in maternal circulation was determined to be approximately 13.8 minutes post-delivery.

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