InsP3-induced Ca2+ excitability of the endoplasmic reticulum (original) (raw)

The paper discusses the mechanisms of calcium (Ca2+) excitability in the endoplasmic reticulum (ER), specifically focusing on the role of inositol 1,4,5-trisphosphate (InsP3) in regulating intracellular Ca2+ levels. It highlights the involvement of SERCA pumps and IP3 receptors (IP3Rs) in Ca2+ uptake and release, emphasizing the interplay between calcium signaling and cellular responses. The findings suggest that InsP3-induced Ca2+ signaling leads to oscillatory patterns that are fundamental for cellular excitability and efficient signal transduction.