Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats (original) (raw)
2015, Pharmacological Reports
AI-generated Abstract
This study investigates the non-lipid effects of simvastatin on paraoxonase 1 (PON1) and butyrylcholinesterase (BuChE) activity, as well as malondialdehyde (MDA) levels, in normolipidemic rats. Over a 21-day treatment period with 10 mg/kg/day of simvastatin, significant decreases in PON1 activity and MDA concentrations were observed across plasma and various tissues, alongside an increase in BuChE activity. These effects highlight simvastatin's potential antioxidant benefits in cardiovascular disorders, but also raise concerns regarding its role in Alzheimer's disease due to elevated BuChE levels.