r-Sm14 - pRSETA efficacy in experimental animals (original) (raw)

Among parasitic infections, schistosomiasis is one of the most important diseases. This disease is a major cause of morbidity in the world. It ranks with malaria and tuberculosis in this regard. Up to 300 million people are infected with schistosomes. The infection is endemic to 76 countries where over 600 million people are at risk. Around 10% of the infected individuals present severe disease. In previous studies on the search for protective antigens against the Schistosoma mansoni cercariae infection, the characterization of Sm14 cDNA, which codes for a 14 kDa protein, that belongs to the family of fatty acid-binding proteins , was described. The Sm14 cDNA was further ex-This work was supported by Fiocruz, Fapesp, CNPq and Fundação Butantan.