Influence of heat treatment on spray-dried mixtures of Amioca starch and Carbopol 974P used as carriers for nasal drug delivery (original) (raw)
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Effect on the nasal bioavailability of co-processing drug and bioadhesive carrier via spray-drying
International journal of pharmaceutics, 2009
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AAPS PharmSciTech, 2006
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Journal of Pharmacy and Chemistry, 2014
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IOSR Journal Of Pharmacy , 2020
Sumatriptan is having high first pass metabolism leading to low bioavailability (absolute Bioavailability 14% in humans).So there is a need to improve the nasal bioavailability by improving nasal penetration because of long duration of retention. The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery.The objective of this work was to improve the nasal bioavailability of antimigraine drug, Sumatriptan Succinate by increasing its nasal retention time as well as by means of nasal permeation.To improve the nasal retention time of Sumatriptan Succinate, it has been formulated as In-situ mucoadhesive gel by using blend of Poloxamer 407 and HPMC K4 M. The In-vitro tests performed for mucoadhesive strength and drug diffusion showed that nasal In-situ gelling formulations prepared were having good mucoadhesive strength with very good drug diffusion. The drug release mechanism gel matrices was found to be anomalous and following the Higuchi equation and the diffusion follows Fickian diffusion mechanism. The formulations were evaluated for physiochemical parameter like gelation temperature,viscosity, gel strength, drug content , FTIR and DSC. FTIR and DSC studies were carried out on pure drug as well as for all excipients used in the final formulation and exhibited no interaction.So, this study points to the potential of mucoadhesive In-situ nasal gel of Sumatriptan Succinate in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved nasal bioavailability.