Recurrent and fatal epithelial-myoepithelial carcinoma of the parotid (original) (raw)
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Epithelial myoepithelial carcinoma of parotid gland-a case report
Epithelial-Myoepithelial Carcinoma is a rare malignant salivary gland neoplasm. It is also known as adenomyoepithelioma. It accounts for less than 1% of all salivary gland neoplasms. This unusual salivary gland tumors is first described by Donath et al in 1972. This tumor occurs in sixth decade and beyond having a female predominance. Parotid gland is the most commonly involved followed by submandibular gland and palate. Herein we are presenting a rare case of Epithelial-myoepithelial carcinoma of parotid gland.
Epithelial-Myoepithelial Carcinoma of the Parotid
Acta Cytologica, 1999
Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features.
Epithelial–myoepithelial carcinoma of the parotid gland
Auris Nasus Larynx, 2003
Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features.
Parotid Myoepithelial Carcinoma in a Pediatric Patient with Multiple Recurrences: Case Report
Case Reports in Oncology
Myoepithelial carcinoma of the salivary glands is a rare entity, with scarce amount of case reports in the literature. Due to its infrequency, its diagnosis is usually difficult and uncertain. Although there are reports of locoregional recurrences and distant metastases, its low incidence and varied biological behavior limits the clinical evidence that can be used to predict the prognosis and determine the course of treatment. We present a 23-year-old female patient without past medical history with an initial 1-year history of volume increase in the right parotid region of tumor aspect and painful on palpation. As a malignancy was suspected, a total parotidectomy was performed, reporting in the deep lobe a parotid myoepithelial carcinoma with vascular and neural invasion, negative borders, and 3–9 negative regional nodes. During her 16-year clinical evolution, she presented approximately every 2 years and a total of 9 locoregional recurrences and hepatic metastases, including cervi...
Myoepithelial carcinoma of the parotid gland
Collegium antropologicum, 2010
Rare malignant tumor of the salivary gland, a myoepithelial carcinoma, arose de novo in the right parotid gland. The initial tumor was composed predominantly of myoepithelial cells. Subsequently the tumor recurred three times, with infiltration of the bones of the cranial base. Histological examination showed sarcomatoid neoplasm composed of malignant spindle cells with high mitotic rate and perineural invasion. There was no involvement of cervical lymph nodes. Immunohistochemistry demonstrated myoepithelial differentiation: tumor cells were positively stained with vimentin, alpha smooth muscle actin and S-100 protein antibodies, and focal positively was noticed with cytokeratin (AE1/AE3) antibody. Large number of tumor cells nuclei was reactive with the monoclonal anti-p63 antibody, clone 4A4. Myoepithelial carcinomas exhibit a wide spectrum of morphological heterogeneity and for that reason could be confused with many tumors. Cytoarchitectural patterns and immunohistochemical prof...
A Huge Myoepithelial Carcinoma of Parotid Gland in 99 Years Old Patient
2021
Myoepithelial carcinoma, also named malignant myoepithelioma or epithelial – myoepithelial carcinoma, is an unusual neoplasm arising from neoplastic myoepithelial cells. This tumor accounts for 0, 1–0, 45% of all salivary tumors; these neoplasms can involve both major and minor salivary glands. Myoepithelial carcinomas generally occur in adults or elderly. The described cases in literature have an average age of 52, 5 years, with a range from 7 to 81 years. This report shows a clinical case of a centenarian woman with a huge myoepithelial carcinoma of the right parotid gland.
Journal of Oral and Maxillofacial Pathology, 2022
Epithelial myoepithelial carcinoma (EMC) is an uncommon low-to-intermediate grade salivary gland malignancy that accounts for 1% of all tumors arising in salivary glands. About 80% of these tumors affect the parotid gland. These lesions either arise de novo or from existing pleomorphic adenoma (PA). Histologically, these tumors reveal a biphasic cell population with inner ductal epithelial cells and peripheral myoepithelial cells. There are many histologic variants of EMC, but sebaceous, verocay-like differentiation and high-grade transformation is very rarely reported. This article describes a 48-year-old female patient diagnosed with EMC ex PA with unique histologic differentiation.
International Seminars in Surgical Oncology Isso, 2007
Background: Ultrasound (US), Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are widely used in the clinical diagnosis of parotid gland tumors and their efficacy in identifying benign lesions is well documented. However, problems arise when facing some malignant lesions. Only few cases of salivary gland low grade malignant tumors have been previously reported in the literature complete with the radiological features. Case presentation: We here describe a case of epithelial-myoepithelial carcinoma (EMC) of the parotid gland, a low grade malignant tumor, with spread to an intraparotid lymph node and with CT and MRI findings mimicking a benign lesion. Conclusion: All the images revealed sharply outlined profiles and a homogeneous enhancement of the nodule, suggesting a benign tumor and demonstrating that a radiological evaluation of the lesion alone may be unsatisfactory and misleading in the diagnosis of salivary gland tumours, especially in the case of low grade malignant tumors, such as EMC.
Case Reports in Otolaryngology, 2014
Dediferentiation is deined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dediferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 6-year-old female, presented with a let parotid mass of 20-year duration. Histopathologic results showed that there was only one area of typical epithelial-myoepithelial carcinoma, with foci of poorly diferentiated adenocarcinoma (not otherwise speciied; NOS) and clear cytoplasm in the parotid gland. Immunohistochemical staining results showed SMA (+), P63 (+), CK8 (+), and S100 (+) on epithelial cells. A review of the literature revealed 22 previously reported cases of dediferentiated epithelial-myoepithelial carcinoma. In these cases, the malignant tumors that dediferentiated from epithelialmyoepithelial carcinoma were adenoid cystic carcinoma, actinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and intraductal carcinoma. In our case, the malignant tumor that dediferentiated from the epithelialmyoepithelial carcinoma was a poorly diferentiated adenocarcinoma. Histopathological results showed that metastases were not seen in the neck-dissection material. As a result, our case will make a contribution to the literature in terms of prognosis, because there are very few reported cases of dediferentiated adenocarcinoma development arising from epithelial-myoepithelial carcinoma.
Epithelial-Myoepithelial Carcinoma of the Salivary Glands
Otolaryngology-Head and Neck Surgery, 2015
Objective. Epithelial-myoepithelial carcinoma (EMC) is a rare neoplasm of the salivary glands. In this study, we aim to examine the demographic, clinicopathologic, and survival features of EMC using a population-based approach. Study Design and Setting. Retrospective cohort study. Subjects and Methods. The Surveillance, Epidemiology, and End Result (SEER) database (1973-2010) was queried for EMC of the major salivary glands. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier and Cox proportional hazards models. Results. In total, 246 cases were available for frequency analysis and 207 for survival analysis. Mean 6 SD age at diagnosis was 63.8 6 15.4 years. EMC affected females more frequently (57.3%). Distant metastases were present at diagnosis in only 4.5% of cases. Overall disease-specific survival (DSS) at 60, 120, and 180 months was 91.3%, 90.2%, and 80.7%, respectively. Patients with low-grade histology had significantly better survival at 180 months relative to those with high-grade tumors (90.6% vs 0.0%, P = .0246). When stratified by tumor size, patients with lesions .4 cm had the worst survival at 180 months (58.8%, P = .0003). All but 9 of the 207 cases available for survival analysis underwent surgery. A total of 85 patients (41.1%) received radiotherapy in addition to surgery. No survival benefit was noted for patients who received radiotherapy compared with those who did not (P = .4832). Conclusion. This report represents the largest series of EMC to date. Despite being regarded as a low-grade, indolent tumor, a significant fraction of our cohort underwent radiotherapy in addition to surgery, with no apparent added survival benefit.