Topically Applied Vitamin C Enhances the mRNA Level of Collagens I and III, Their Processing Enzymes and Tissue Inhibitor of Matrix Metalloproteinase 1 in the Human Dermis1 (original) (raw)
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The Roles of Vitamin C in Skin Health
Nutrients, 2017
The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis. Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage. This knowledge is often used as a rationale for the addition of vitamin C to topical applications, but the efficacy of such treatment, as opposed to optimising dietary vitamin C intake, is poorly understood. This review discusses the potential roles for vitamin C in skin health and summarises the in vitro and in vivo research to date. We compare the efficacy of nutritional intake of vitamin C versus topical application, identif...
Evaluation of selected skin parameters following the application of 5% vitamin C concentrate
Journal of cosmetic dermatology, 2018
Ascorbic acid is a substance with confirmed anti-free-radical properties. It triggers the collagen synthesis, has a depigmenting effect and seals blood vessels. All these properties have a significant effect of the skin's appearance. The characteristic traits of capillary skin include telangiectasias as well as erythema, which might consolidate in the future, along with the feeling of burning and increased skin sensitivity. Study and evaluation of selected parameters of capillary skin after the application of 5% vitamin C concentrate throughout the period of 6 weeks with the use of instrumental tests and questionnaires. The research was conducted on a group of 30 women ranging from 30 to 60 years of age with capillary skin indicating visible signs of erythematous plaques. The concentrate was applied once a day. Analyses of skin conditions were conducted four times: before the launch of the research D(0), after two 2D(14), after four 4D(28), and after 6 D(42) weeks of application...
The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach
Clinical, Cosmetic and Investigational Dermatology, 2015
Background: Imagistic methods stand as modern, non-invasive, and objective means of assessing the impact of topical cutaneous therapies. Objective: This study focuses on the evaluation, by high-frequency ultrasound, of the cutaneous changes induced by topical use of a vitamin C complex at facial level. Methods: A vitamin C-based solution/Placebo moisturizer cream was applied at facial level of 60 healthy female subjects according to a predetermined protocol. Ultrasonographic images (Dermascan C, 20 MHz) were taken from zygomatic level initially, at 40 and 60 days after therapy. The following parameters were assessed for every subject: thickness of the epidermis and dermis (mm), the number of low (LEP), medium (MEP), high echogenic pixels (HEP), and the number of LEP in the upper dermis/lower dermis (LEPs/LEPi). Results: LEP decreased significantly in all age categories during and after therapy, but especially in the first 2 age intervals, up to the age of 50 (P=0.0001). MEP and HEP, pixel categories that quantify protein synthesis also had an age-dependent evolution in the study, increasing significantly in all age categories but most of all in the first age interval (P=0.002). Our ultrasonographic data suggest that collagen synthesis increased significantly after topical vitamin C therapy, and is responsible for the increase in MEP and HEP and consequent decrease of the LEP. Conclusion: Our study shows that topically applied vitamin C is highly efficient as a rejuvenation therapy, inducing significant collagen synthesis in all age groups with minimal side effects.
The Role of Topical Vitamin C and Its Derivative in Promoting Skin Wound Healing in Rats
2013
Purpose To verify the role of topical L-ascorbic acid and magnesium ascorbyl phosphate in promoting rats’ skin wound healing through the number of macrophages, neovessels and collagen thickness. Method 27 male Rattus novergicus at about 3 months old were used. Three 15 mm longitudinal incisions were made at each rat’s back at different locations and sutured afterwards. The central wounds (CG) were cleaned with normal saline and savlon daily. The left wounds (TG 1) were cleaned daily and treated with 20% L-ascorbic acid serum. The right wounds (TG 2) were cleaned daily and treated with 15% magnesium ascorbyl phosphate serum. Skin specimens were collected on the 3rd, 7th and 21st days from 9 different rats at each period. The sections were stained with hematoxyllin-eosin for examining the number of macrophages, neovessels and collagen thickness. Result Both L-ascorbic acid and magnesium ascorbyl phosphate acted on every stage of healing process. Magnesium ascorbyl ph...
Biochemical and Biophysical Research Communications, 2009
Intrinsic skin ageing is characterized by atrophy and loss of elasticity. Although the skin hypertrophy induced by photoageing has been studied, the molecular mechanisms of skin atrophy during ageing remain unclear. Here, we report that copper/zinc superoxide dismutase (CuZn-SOD)-deficient mice show atrophic morphology in their skin. This atrophy is accompanied by the degeneration of collagen and elastic fibers, and skin hydroxyproline is also significantly reduced in deficient mice. These imply that the dysfunction of collagen and elastin biosynthesis are involved in the progression of skin thinning. Furthermore, transdermal administration of a vitamin C derivative which can permeate through the membrane, completely reversed the skin thinning and deterioration of collagen and elastin in the mutant mice. These indicate that the vitamin C derivative is a powerful agent for alleviating skin ageing through regeneration of collagen and elastin. The CuZn-SOD-deficient mice might be applicable to evaluation of therapeutic medicines against skin ageing.
British Journal of Dermatology, 2003
Ageing skin is characterized by fine lines, wrinkles, lentigines, dyspigmentation and increased coarseness. Topical preparations alleged to combat these changes abound in the over-the-counter market. Some of the most popular ingredients used in these products are vitamins, minerals and botanical extracts. Proposed mechanisms for antiageing effects on skin range from antioxidant properties to improved collagen synthesis or protection from collagen breakdown. Despite the media attention and consumer popularity that these ingredients have generated, there have been few scientific studies to support these claims. In this report, we review recent published studies on the most common of these ingredients for the topical photoprotection and the treatment of ageing skin. Recently, consumer and media attention has focused specifically on products utilizing 'natural' ingredients such as vitamins, minerals and botanical extracts. These ingredients have the appeal of appearing wholesome and 'organic'. Although scientific evidence shows that some of these ingredients do have possible in vitro antiageing activity, the question remains whether it is possible to deliver adequate doses to the skin in vivo. and to produce either histological or clinical improvement of wrinkles, lentigines, coarseness, pigmentary changes, dryness and other characteristics of ageing skin. This article reviews recent published studies on the most common of these 'natural ingredients' and summarizes their proposed effects on ageing skin.
Topically applied vitamin C increases the density of dermal papillae in aged human skin
BMC dermatology, 2004
The influence of ageing on the density of the functional entities of the papillae containing nutritive capillaries, here in terms as the papillary index, and the effect of topically applied vitamin C were investigated by confocal laser scanning microscopy (CLSM) in vivo. The age dependency of the papillary index was determined by CLSM on 3 different age groups. Additionally, we determined the effect of a topical cream containing 3% vitamin C against the vehicle alone using daily applications for four months on the volar forearm of 33 women. There were significant decreases in the papillary index showing a clear dependency on age. Topical vitamin C resulted in a significant increase of the density of dermal papillae from 4 weeks onward compared to its vehicle. Reproducibility was determined in repeated studies. Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for part...