Immune response to lentiviral bilirubin UDP-glucuronosyltransferase gene transfer in fetal and neonatal rats (original) (raw)

AI-generated Abstract

Inherited liver diseases can be classified into those directly affecting liver function, leading to significant damage, and those that impact the body while leaving the liver largely unharmed. This paper discusses various inherited liver disorders, particularly focusing on progressive familial intrahepatic cholestasis (PFIC) and its subtypes, which involve mutations in ABC transporters. The challenges posed by these disorders highlight the potential for therapeutic approaches such as hepatocyte transplantation to facilitate recovery and mitigate liver damage.