5α-Androstane-3β,7α,17β-triol and 5α-androstane-3β,7β,17β-triol as substrates for the human 11β-hydroxysteroid dehydrogenase type 1 (original) (raw)

Isomerase Epimerase Oxido-reductase 7Beta abstract Several studies have shown that the native 7␣-hydroxy-dehydroepiandrosterone (7␣hydroxy-DHEA) is a substrate for the human 11␤-hydroxysteroid dehydrogenase type 1 (11␤-HSD1) which converts the 7␣-into the 7␤-epimer through an oxido-reduction process. Research on the 11␤-HSD1 has investigated its function and structure through using native glucocorticoid substrates and known inhibitors. Other steroid substrates are also of interest. Among testosterone metabolites, 5␣-androstane-3␤,17␤-diol (Adiol) is a substrate for the cytochrome P450 7B1 which produces 5␣-androstane-3␤,7␣,17␤-triol (7␣-Adiol).