Limitations of statin monotherapy for the treatment of dyslipidemia: a projection based on the Canadian lipid study – observational (original) (raw)

Objective: Several randomized controlled trials indicate that a low density lipoprotein cholesterol (LDL-C) target 52.0 mmol/L is appropriate for individuals at high risk of coronary artery disease (CAD). Recently released Canadian lipid management guidelines (2006) have incorporated this evidence into their recommendations. A cross-sectional study of patients treated with statins for at least 8 weeks (CALIPSO) was used as a basis to project the ability of statin monotherapy in getting high CAD-risk patients to an LDL-C level 52.0 mmol/L.