Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: A mechanism of action (original) (raw)

AI-generated Abstract

Psychostimulants like amphetamine enhance dopaminergic activity at mesolimbic synapses, contributing to their rewarding effects. This study investigates how these substances impact the pH gradients in midbrain dopaminergic neurons and chromaffin granules, suggesting that the inhibition of acidification by psychostimulants is a key mechanism for their action. The findings reveal that several psychostimulants reduce pH gradients, which in turn decreases neurotransmitter uptake and increases release, establishing a vital link between pH modulation and the pharmacological effects of these compounds.

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