Evaluation of the Use of a Blood Pool Contrast Agent (Gadofoveset Trisodium) for the Assessment of Peripheral Vascular Disease with Contrast Enhanced Magnetic Resonance Angiography (original) (raw)

Abstract

PURPOSE/AIM To demonstrate advantages and limitations of conventional gadolinium-based versus blood pool contrast material (gadofosveset) for clinical magnetic resonance angiography (MRA) evaluation of blood vessels. To explore techniques to optimize performance of MRA using both conventional and blood pool agents. CONTENT ORGANIZATION Clinical MRA is a powerful tool for the evaluation of abdominopelvic and peripheral vasculature, but suffers some limitations owing to the short intravascular half-life of conventional gadolinium contrast materials, relatively low T1 shortening effects, and high leakage rate into the interstitial space. Several methods, including timing bolus, bolus tracking, repeat dosing, and time resolved imaging may be used to improve MRA results, but each method has tradeoffs. Alternatively, blood pool MR contrast material (gadofosveset) may be utilized to provide most of the benefits of first-pass imaging and also allow steady state imaging of abdominal/lower ex...

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