Evaluacija Albizia zygia gume kao veziva u tabletama (original) (raw)
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Albizia procera gum as an excipient for oral controlled release matrix tablet
Carbohydrate Polymers, 2012
The purpose of this research was to develop and evaluate controlled release matrix tablets of paracetamol based on natural gum exudates of Albizia procera. Procera gum was characterized of its properties like compressibility index, angle of repose, viscosity and moisture content. The interaction between the gum and paracetamol was also studied through differential scanning calorimetry (DSC) and FTIR spectroscopy. Matrix tablets were then prepared by wet granulation method with different concentrations of procera gum and hydroxypropyl methylcellulose (HPMC) and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. Dissolution study was conducted to characterize release mechanism from the matrix system and data were fitted to various kinetic models. The mechanism of drug release from both types of matrix tablets was found to be anomalous type. Results from various evaluations suggested that A. procera gum could be used as drug release retardant in controlled release matrix systems.
Assessment of Ferula Gummosa Gum as a Binding Agent in Tablet Formulations
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Ferula gummosa Boiss. (Apiaceae) is one of the natural plants of Iran. The whole plant, but especially the root, contains the gum resin ìgalbanumî. A study of the comparative effects of galbanum gum and two standard binding agents ñ polyvinylpyrolidone and acacia ñ on characteristics of acetaminophen and calcium carbonate compacts was made. The Ferula gummosa gum was extracted and its swelling index was determined. Acetaminophen and calcium carbonate granules were prepared using the wet granulation method and were evaluated for their micromeritics and flow properties, while the compacts were evaluated for mechanical properties using the hardness, tensile strength and friability. The drug release from acetaminophen compacts were assessed using dissolution studies. The dry powder of Ferula gummosa gum resin (galbanum) yielded 14% w/w of gum using distilled water as extraction solvent. The swelling index indicates that galbanum gum swelled to about 190% of initial volume in distilled water. Thus galbanum gum has the ability to hydrate and swells in cold water. The bulk and tapped densities and the interspace porosity (void porosity) percent of the granules prepared with different binders showed significant difference. The hardness and tensile strength of acetaminophen and calcium carbonate compacts containing various binders was of the rank order PVP > acacia > galbanum gum (p < 0.05) and the friability percent was of the reverse order (p < 0.05). The ranking for the dissolution rate of tablets containing the different binders was PVP > galbanum gum > acacia. The results of mechanical properties of acetaminophen and calcium carbonate compacts indicate that galbanum gum could be useful to produce tablets with desired mechanical characteristics for specific purposes, and could be used as an alternative substitute binder in pharmaceutical industries.
Journal of Pharmaceutical Research, 2010
The individual and interaction effects of gum-binder type (B), binder concentration (C), as well as the relative density (D) of a paracetamol tablet prepared with Delonix regia seed gum (DRSG), acacia gum BP (ACG) and tragacanth gum BP (TRG) on the mechanical {tensile strength (TS) and brittle fracture index (BF)} and disintegration {disintegration time (DT) and crushing strength-friability/disintegration time ratio (CSFR/DT)} properties of the tablets were studied using a 2 3 factorial experimental design. For the TRG/ACG and DRSG/ACG, the individual effects of the variables presented a rank order of D>C>B on the two mechanical properties studied, while a rank order of B>C>D was obtained for the studied disintegration properties. However, considering the TRG/DRSG combination, effect of C was more on the DT (C>D>B), whereas D had more effect on the CSFR/DT (D>C>B). Generally, the interaction between B and C was more on TS and DT than on BFI and CSFR/DT, while a similar result was observed for B and D on BFI and CSFR/DT than on TS and DT. This implies that the B is a very important variable to be considered when combining binders in a formulation.
Pharmaceutical Development and Technology, 2008
A study was made of the comparative effects of polymers obtained from two species of khaya tree -Khaya senegalensis and Khaya grandifoliola -as binding agents in a paracetamol tablet formulation. The mechanical properties of the tablets were assessed using the tensile strength (T), brittle fracture index (BFI) and friability (F) of the tablets while the drug release properties of the tablets were assessed using disintegration and dissolution times. The tensile strength, disintegration and the dissolution times of tablets increased with the increase in binder concentration while F and BFI decreased. K. senegalensis gum produced tablets with stronger mechanical properties with less tendency to laminate, and longer disintegration and dissolution times than K. grandifoliola gum. The results suggest that the polymer gum from K. senegalensis will be more appropriate as a binding agent than the gum from K. grandifoliola when higher mechanical strength and slower release profiles of tablets are desired.
The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre-and post-compression parameters, and were characterized. The optimized PCMT (F 14) formulation showed favorable in vitro release of PC (65%) in 12 h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant (p < 0.001) anticancer activity with 98.25% inhibition at 2000 g/mL (IC 50 = 179.12 g/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC 50 value = 856.58 g/mL) and 93.68% inhibition (IC 50 value = 396.35 g/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24 h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics.
African Journal of …, 2010
The mechanical and release properties of paracetamol tablets formulated with cashew gum (CAG), povidone (PVP) and gelatin (GEL) as binders were studied and compared. The parameters studied were tensile strength (TS), brittle fracture index (BFI), friability (F), disintegration time (DT) and percentage drug released (PDR). Results showed that the TS and BFI values of tablets formulated with CAG were the lowest at all binder concentrations. The friabilities of all formulations were within accepted limits (<1.0%). Disintegration times were longest for GEL formulated tablets and least for PVP formulated ones. At binder concentrations of 1.0-3.0% (w/w) CAG released the highest cumulative amount of drug in 30 min; from 4.0-5.0% (w/w) cumulative amount released became highest for PVP formulated tablets. GEL formulated tablets generally released the least amount. CAG gum therefore having imparted better BFI than PVP or GEL, and does not hinder drug release is strongly recommended as an alternative to the more expensive PVP or GEL for immediate release tablet formulations.
International journal of drug delivery technology, 2022
Pulverised native A. procera (NAP) gum was procured from the University of Mizoram (Mizoram, India). Sodium hydroxide, hydrochloric acid, monochloroacetic acid (99.0%), trisodium phosphate dodecahydrate (mol.wt 380.119 g/mol), and trisodium citrate were obtained from Loba Chemie Pvt. Ltd (Mumbai, India). Methanol of the analytical reagent grade (99% v/v) was purchased from Merk Specialty Pvt. Ltd. (Mumbai, India). All other analytical-grade chemicals ABSTRACT The use of carbohydrate polymers in pharmaceutical formulations as drug delivery carriers has gained significant interest from many perspectives. As an exudate of the Albizia tree, Albizia procera (Mimosaceae), a carbohydrate polymer, is used as an excipient to develop sustained-release drug delivery systems, owing to its biocompatibility and biodegradability. This study was conducted to investigate the influence of carboxymethylation of A. procera gum on rheological properties and drug release from the matrix tablet formulations. The study also revealed the comparative characterization of the native form of A. procera (NAP) as well as the carboxymethylated A. procera (CMAP). The rheological assessments of both polymers under different pH divulged the flow behavior, linear viscoelasticity (LVE), structural deformation, and gel network formation. The drug release from NAP and CMAP matrices of various formulations were evaluated and established correlations with rheology.
Zenodo (CERN European Organization for Nuclear Research), 2023
INTRODUCTION Paracetamol, a 4-hydroxyacetanilide is mainly used as analgesic and antipyretic drug 1. In clinical care paracetamol is usually effective for the pain associated with mild to moderate inflammation, such as sprains and contusions, but not in patients experiencing significant inflammation associated with rheumatoid arthritis or acute gout 2. Paracetamol is formulated as tablets 3 , syrups 4 and suspensions 5, 6. Paracetamol tablets are given to adult patients who can swallow tablets for the relief of fever, headaches and other minor aches and pains. Tablet is the most commonly used dosage form. Tablet is produced by compression or molding of a mixture of the active pharmaceutical ingredient (API) and the required excipients. Excipients are inert materials or aids that are added during the production of tablets. Excipients, such as binders, diluents, lubricants and glidants help to impart satisfactory processing and compression characteristics to the tablet formulation while the others such as colours, disintegrants, surfactants, flavours, sweeteners, anti-oxidants, polymers or ABSTRACT ARTICLE DETAILS Paracetamol is mainly used as analgesic and antipyretic drug. This study was conducted to evaluate the binding property of Irvingia gabonensis gum (IGG) in paracetamol tablet formulations in the presence of either maize starch or microcrystalline cellulose as disintegrant. IGG was isolated by acetone precipitation of the filtrate from the maceration of the powdered seeds of Irvingia gabonensis (Irvingiaceae) in distilled water for 24 h. Paracetamol granules were prepared using the wet granulation method. They were produced by using various concentration of IGG as binder, maize starch or microcrystalline cellulose as disintegrants and lactose as filler. The different formulations of paracetamol granules were mixed with magnesium stearate and talc and compressed into the respective tablets. The tablets were evaluated based on uniformity of weight, tablet hardness, friability, disintegration time and in vitro drug release. The tablet hardness for the paracetamol tablet formulations ranged from 2.27±0.09 to 8.00±0.54 Kgf. The friability values ranged from 0.21 ± 0.04 to 3.40±0.10%. The disintegration time ranged from 3.00±0.10 to 23±0.50 min. Tablets from all the formulations released up to 70% of their paracetamol contents within 25 min. For all the formulations, as the binder concentration increased the rate of drug release decreased. For tablets prepared using IGG as binder; formulations that contain microcrystalline cellulose as disintegrant had better release profile than those prepared using maize starch as disintegrant. The study shows that IGG have good binding property. Paracetamol tablets formulated using IGG as binder have comparable hardness value but lower disintegration time than those formulated using maize starch mucilage as binder.
Determination of Efficacy of a Natural Tablet Binder: Characterization and In- Vitro Release Study
Asian Journal of Pharmaceutical and Clinical Research, 2014
Objective: The objective of the study concerns the evaluation of gum Odina as a novel pharmaceutical aid for the development of tablet formulation. Methods: The tablet weight (850mg) and thickness (8mm) was kept constant. Paracetamol was used as reference drug. Wet granulation technique was used for the preparation of Paracetamol granules. The binder concentrations used in the formulation were 0.125%, 0.250%, and 0.375%. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including; IR spectroscopy, Micromeritics, tablet hardness, friability, disintegration time and in-vitro drug release. Compatibility of the drug with the gum was studied using FTIR.