Bimodality Lung Cancer Screening in High-risk Patients: a preliminary report (original) (raw)
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Despite the promising results achieved so far in long-term survival after lung transplantation (LuTx), airway complications (ACs) still arise in the post-operative period. Early diagnosis and prompt treatment of ACs play a critical role in preventing their onset. Specifically, large bronchi ischemia has been recognized as a triggering factor for ACs. Autofluorescence bronchoscopy, which was first introduced for early cancer diagnosis, displays ischemic mucosae as red spots, while normal vascularized mucosae appear in green. The aim of this study is to investigate whether a significant correlation exists between ACs and the red/green (RG) ratio detected on scheduled autofluorescence bronchoscopy up to 1 year after LuTx. This prospective, observational, single-center cohort study initially considered patients who underwent LuTx between July 2014 and February 2016. All patients underwent concomitant white-light and autofluorescence bronchoscopy at baseline (immediately after LuTx), on ...
Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment
Thorax, 2007
This is a preliminary report of an ongoing prospective bimodality lung cancer surveillance trial for high-risk patients. Bimodality surveillance incorporates autofluorescence bronchoscopy (AFB) and spiral CT (SCT) scanning in high-risk patients as a primary lung cancer surveillance strategy, based entirely on risk factors. AFB was used for surveillance and findings were compared with conventional sputum cytology for the detection of malignancy and pre-malignant central airway lesions. 402 patients registering at Roswell Park Cancer Institute were evaluated with spirometric testing, chest radiography, history and physical examination, of which 207 were deemed eligible for the study. For eligibility, patients were required to have at least two of the following risk factors: (1) > or =20 pack year history of tobacco use, (2) asbestos-related lung disease on the chest radiograph, (3) chronic obstructive pulmonary disease with a forced expiratory volume in 1 s (FEV(1)) <70% of pred...
Autofluorescence bronchoscopy for lung cancer surveillance 1 based on risk assessment 2 3
2006
Autofluorescence bronchoscopy for lung cancer surveillance 1 based on risk assessment 2 3 Gregory Loewen*, Nachimuthu Natarajan, Dongfeng Tan, Enriqueta Nava, 4 Donald Klippenstein, Martin Mahoney, Michael Cummings, Mary Reid 5 6 a Pulmonary Division, Department of Medicine, Roswell Park Cancer 7 Institute, Buffalo, NY 14263, USA 8 b Division of Cancer Prevention and Population Sciences, Roswell Park 9 Cancer Institute, Buffalo, NY 14263, USA 10 c Department of Pathology and Laboratory Medicine, University of Texas 11 Health Science Center, Houston, TX 77030, USA 12 d Department of Cytopathology, Roswell Park Cancer Institute, Buffalo, NY 13 14263, USA 14 e Department of Diagnostic Radiology, Roswell Park Cancer Institute, 15 Buffalo, NY 14263, USA 16 17 * Corresponding author. Telephone: +1 716 845 3099; fax +1 716 845 8935. 18 E-mail address: gregory.loewen@roswellpark.org (G. Loewen). 19 20 Thorax Online First, published on November 13, 2006 as 10.1136/thx.2006.068999