(+)-Hydrastine, a potent competitive antagonist at mammalian GABAA receptors (original) (raw)

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The study presents (+)-hydrastine as a potent competitive antagonist of GABAA receptors, demonstrating its greater potency compared to bicuculline across various test systems. Isolated from Corydalis stricta, (+)-hydrastine may offer improved solubility and stability, suggesting its potential in developing selective GABAA receptor antagonists. Findings indicate that (+)-hydrastine's structural characteristics could aid in designing more selective pharmacological agents targeting distinct GABAA receptor subtypes.

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