Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors (original) (raw)
Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors
Andres Trabanco
Bioorganic & Medicinal Chemistry Letters, 2013
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Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors
Battistina Asproni, Gabriele Murineddu
Bioorganic & Medicinal Chemistry, 2011
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Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A
Robert Mach
European Journal of Medicinal Chemistry, 2011
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CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors
maulik patel
Bioorganic & Medicinal Chemistry, 2008
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Design, synthesis and evaluation of N2,N4-diaminoquinazoline based inhibitors of phosphodiesterase type 5
Nattakarn Pobsuk
Bioorganic & Medicinal Chemistry Letters, 2018
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Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)
Ji Ma
Journal of medicinal chemistry, 2014
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Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors
Sreedhara Voleti
Bioorganic & Medicinal Chemistry Letters, 2013
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Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia † † Coordinates of the PDE10A crystal structures have been deposited in...
Frank Menniti
Journal of Medicinal Chemistry, 2009
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Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors
Hengming Ke
ChemMedChem, 2009
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Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1
Jennifer Liras
Journal of medicinal chemistry, 2018
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Small-Molecule Phosphodiesterase Probes: Discovery of Potent and Selective CNS-Penetrable Quinazoline Inhibitors of PDE1
Jenna Head, Frank Menniti
MedChemComm, 2014
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Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors
Julio Alvarez-Builla
Bioorganic & Medicinal Chemistry, 2013
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Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
Hengming Ke
Journal of Medicinal Chemistry, 2010
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Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors
Michael Minnicozzi
Bioorganic & Medicinal Chemistry Letters, 2007
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Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogs of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline
Robert Alvarez
Journal of Medicinal Chemistry, 1988
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cAMP-dependent phosphodiesterase inhibition and SAR studies on novel 6,8-disubstituted 2-phenyl-3-(substituted benzothiazole-2-yl)-4[3H]-quinazolinone
Dr Sachin S Laddha
Medicinal Chemistry Research, 2009
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Highlight of New Phosphodiesterase 10A Inhibitors Using Molecular Docking
Abderrahmane Bensegueni
Current Research in Bioinformatics
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Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors †
John Humphrey
Journal of Medicinal Chemistry, 2007
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Quinazolines: Combined type 3 and 4 phosphodiesterase inhibitors
Reto Naef
Bioorganic & Medicinal Chemistry Letters, 1998
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Safety and Efficacy of New 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine Analogs as Potential Phosphodiesterase-4 Inhibitors in NIH-3T3 Mouse Fibroblastic Cells
maryam motamedi
Chemical Biology & Drug Design, 2011
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Synthesis and In Vitro Evaluation of 8-Pyridinyl-Substituted Benzo[e]imidazo[2,1-c][1,2,4]triazines as Phosphodiesterase 2A Inhibitors
RIEN RITAWIDYA
Molecules
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Synthesis of triazole Schiff bases: Novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1
Khalid Khan
Bioorganic & Medicinal Chemistry, 2014
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Phosphodiesterase 10 (PDE10) inhibitors: an updated patent review (2014-present)
Agnieszka Zagórska
Expert Opinion on Therapeutic Patents, 2019
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Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design
Hengming Ke
Journal of Medicinal Chemistry, 2012
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