Influence of exercise training on markers of tumor microenvironment in breast cancer: a comprehensive meta-analysis from 15 trials (original) (raw)

Abstract

Objective: To establish the influence of exercise interventions on tumor microenvironment-related markers, including inflammatory cytokines, C-reactive protein (CRP) and Insulin-like growth factors (IGF's) in breast cancer survivors. Methods: PRISMA statement was followed. MEDLINE, Ovid, EMBASE and CENTRAL were searched for randomized controlled trials until February 2014. Heterogeneity was measured by using the I2 statistics. A random-effects models was used in presence of high statistical heterogeneity (I2>50%). Meta-regression analyses were also conducted. Results: Data from 15 studies were pooled (n=1,447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP, IL-2, IL-10, IGF-I, IGF-II and IGFBP-3 (p<.05). Non-significant differences were found for IL-6 and TNF-α. Meta-regression models showed that duration (>40 minutes/session) and training intensity (>70% maximum heart rate) of the exercise were predictors of the effects on tum...

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