Nuclear mechanics during cell migration (original) (raw)

Cell migration is a crucial process in various physiological and pathological contexts, shaped by the mechanical properties of cells and their surrounding environment. This paper discusses the mechanics of the cell nucleus during migration, detailing how nuclear stiffness and deformability influence cell movement through different extracellular matrices. The study highlights specific mechanisms, such as ECM degradation and cellular remodeling, that enable cells to navigate narrow spaces and emphasizes the significance of nuclear dynamics in cancer cell invasion.