Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma (original) (raw)

AI-generated Abstract

Primary angle closure glaucoma (PACG) is a significant cause of blindness, particularly in Asian populations. This study conducted a genome-wide association analysis involving 1,854 PACG cases and 9,608 controls, followed by replication in an independent cohort of 1,917 cases and 8,943 controls. Significant associations were found at three new susceptibility loci: rs11024102 in PLEKHA7, rs3753841 in COL11A1, and rs1015213 between PCMTD1 and ST18, suggesting a genetic basis for susceptibility to PACG.

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