Comparison of Specific Surface Areas of a Micronized Drug Substance as Determined by Different Techniques (original) (raw)

Studies in Surface Science and Catalysis, 2000

Abstract

Drug Substance (DS) Specific Surface Area (SSA), porosity and Particle Size Distribution (PSD) are important physical characteristics for pharmaceutical applications. For instance the DS surface area can greatly influence the dissolution rate which, in turn, might affect bioavailability. Several analytical methods can be used to characterise the DS and determine the powder SSA: measurements by gas adsorption (BET method) and

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