In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin (original) (raw)

This study investigates the role of indomethacin in enhancing the renal medullary cyclic AMP response to vasopressin, a hormone that regulates water permeability in the kidney. Prior in vitro research indicated that prostaglandin E1 (PGE1) inhibits the action of vasopressin, prompting the hypotheses tested in this research. Results show that in vivo administration of indomethacin successfully potentiates the hydro-osmotic effect of vasopressin, suggesting a potential therapeutic avenue for modulating renal responses in conditions impacting water balance.