original ) (raw )Affinity selection-mass spectrometry screening techniques for small molecule drug discovery
Allen Annis , Charles E Whitehurst , Xianshu Yang
Current Opinion in Chemical Biology, 2007
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A Carboxy-Terminal Affinity Tag for the Purification and Mass Spectrometric Characterization of Integral Membrane Proteins
Robert Molday
Journal of Proteome Research, 2009
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Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays
Alessandro Pedretti
International Journal of Molecular Sciences
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Identification of a [3H]Ligand for the Common Allosteric Site of Muscarinic Acetylcholine M2 Receptors
MARIO ACUÑA CID
Molecular Pharmacology, 1998
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{"__content__"=>"Probing the binding site of novel selective positive allosteric modulators at the M muscarinic acetylcholine receptor.", "sub"=>{"__content__"=>"1"}}
Celine Valant
Biochemical pharmacology, 2018
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Quantitative Determination of Protein–Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry
Chengfeng Ren
Analytical Chemistry, 2018
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Muscarinic Receptors as Model Targets and Antitargets forStructure-Based Ligand Discovery
Peter Gmeiner
Molecular Pharmacology, 2013
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Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms
Katie Leach
The Journal of biological chemistry, 2010
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Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands
Douglas Bonhaus
BMC Pharmacology, 2009
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Potentiation of Muscarinic M3 Receptor Activation through a New Allosteric Site with a Novel Positive Allosteric Modulator ASP8302
Kenichiro Ishizu
Journal of Pharmacology and Experimental Therapeutics, 2021
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A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M2 Muscarinic Receptor
Mathai Mammen
Molecular Pharmacology, 2007
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Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity
alejandro rodriguez
Molecular Pharmacology, 2009
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Ligand-Specific Changes in M 3 Muscarinic Acetylcholine Receptor Structure Detected by a Disulfide Scanning Strategy †
Kenneth A Jacobson
Biochemistry, 2008
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Affinity Ligand Selection from a Library of Small Molecules: Assay Development, Screening, and Application
Larry Hardy
Biotechnology Progress, 2008
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Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system
Huiyong Yin
2010
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MOL #33746 1 A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M 2 muscarinic receptor MOL #33746 2 Running title A novel multivalent ligand for the M 2 muscarinic receptor Author for correspondence
Mathai Mammen
2020
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{"__content__"=>"Structure-based discovery of selective positive allosteric modulators of antagonists for the Mmuscarinic acetylcholine receptor.", "sub"=>{"__content__"=>"2"}}
Celine Valant
Proceedings of the National Academy of Sciences of the United States of America, 2018
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Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M 1 Muscarinic Acetylcholine Receptor
Emma Van Der Westhuizen
ChemMedChem
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Throughput and Efficiency of a Mass Spectrometry-Based Screening Assay for Protein–Ligand Binding Detection
Michael Fitzgerald
Journal of the American Society for Mass Spectrometry, 2008
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Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein: De-emphasizing the Geography of Binding
Terry Kenakin
Molecular Pharmacology, 2008
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The Role of Orthosteric Building Blocks of Bitopic Ligands for Muscarinic M1 Receptors
Daniela Volpato
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Utility of an "allosteric site-impaired" M2 muscarinic acetylcholine receptor as a novel construct for validating mechanisms of action of synthetic and putative endogenous allosteric modulators
Celine Valant
Molecular pharmacology, 2018
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Application of Fragment-Based Drug Discovery to Membrane Proteins: Identification of Ligands of the Integral Membrane Enzyme DsbB
John Bushweller
Chemistry & Biology, 2010
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Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors
Esther Kellenberger
Journal of Medicinal Chemistry, 2012
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Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases
Dario Doller
Journal of Medicinal Chemistry, 2019
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Impact of species variability and ‘probe-dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor
Christian Felder
British Journal of Pharmacology, 2011
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The Development of a High-Content Screening Binding Assay for the Smoothened Receptor
Brandon Turunen
Journal of Biomolecular Screening, 2012
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The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor
Christian Felder
Molecular pharmacology, 2011
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An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries
Kristin Rosner , Carston Wagner , Gerald Shipps , is pat , John Athanasopoulos
International Journal of Mass Spectrometry, 2004
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Muscarinic receptor family interacting proteins: Role in receptor function
Manuel Narvaez
Journal of Neuroscience Methods, 2011
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