Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test (original) (raw)

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015

Abstract

Determining cervical precancer risk amongst HIV-infected women who despite a normal Pap test are oncogenic human papillomavirus (oncHPV)-positive is important for setting screening practices. 2,791 HIV-infected and 975 HIV-uninfected women in the Women's Interagency HIV Study were followed semiannually with Pap tests and colposcopy. Cumulative risks of cervical intraepithelial neoplasia 2 or greater (CIN-2+; threshold used for CIN treatment) and CIN-3+ (threshold to set screening practices) were measured in HIV-infected and HIV-uninfected women with normal Pap tests, stratified by baseline HPV results, and also in HIV-infected women with a low-grade squamous intraepithelial lesion (LSIL; benchmark indication for colposcopy). At baseline, 1,021 HIV-infected and 518 HIV-uninfected women had normal Pap tests, of whom 154 (15%) and 27 (5%), respectively, tested oncHPV-positive. The 5-year CIN-2+ cumulative risk in the HIV-infected oncHPV-positive women was 22% (95% CI, 9%-34%), 1...

Howard Strickler hasn't uploaded this paper.

Let Howard know you want this paper to be uploaded.

Ask for this paper to be uploaded.