Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase (original) (raw)
Identification of SD0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase
Tina Kim
Bioorganic & Medicinal Chemistry Letters, 2010
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Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
Kent Miner, Helen McBride, Ryan Wurz
Bioorganic & Medicinal Chemistry Letters, 2010
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Part 1: Structure–Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
Kent Miner, Helen McBride, Ryan Wurz
Bioorganic & Medicinal Chemistry Letters, 2009
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Pyrazole Urea-Based Inhibitors of p38 MAP Kinase: From Lead Compound to Clinical Candidate
Jeffrey Madwed
Journal of Medicinal Chemistry, 2002
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Discovery and Evaluation of 7-Alkyl-1,5-bis-aryl-pyrazolopyridinones as Highly Potent, Selective, and Orally Efficacious Inhibitors of p38α Mitogen-Activated Protein Kinase ⊥ ⊥ Atomic coordinates and structure factors for crystal structure of compound 3d with p38α can be accessed using PDB code 3LHJ
Helen McBride, Ryan Wurz
Journal of Medicinal Chemistry, 2010
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Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy
Bryan Dios
Journal of Medicinal Chemistry, 2005
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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase †
Robert Rzasa
Journal of Medicinal Chemistry, 2008
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Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors
Gary Schieven
Bioorganic & Medicinal Chemistry Letters, 2008
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The pyrazolobenzothiazine core as a new chemotype of p38 alpha mitogen-activated protein kinase inhibitors
Maria Letizia Barreca
Chemical biology & drug design, 2015
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Co-crystal structure determination and cellular evaluation of 1,4-dihydropyrazolo[4,3-c] [1,2] benzothiazine 5,5-dioxide p38α MAPK inhibitors
Maria Letizia Barreca
Biochemical and Biophysical Research Communications, 2019
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Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase
Kevin D Jerome, Jeff Hitchcock, Brian Hickory
Bioorganic & Medicinal Chemistry Letters, 2011
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Dissection of the Recognition Properties of p38 MAP Kinase. Determination of the Binding Mode of a New Pyridinyl−Heterocycle Inhibitor Family
Modesto Orozco
Journal of Medicinal Chemistry, 2007
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p38 MAP kinase inhibitors. Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design
Giovanna Scapin
Bioorganic & Medicinal Chemistry Letters, 2006
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Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)
Jeffrey Madwed
Journal of Medicinal Chemistry, 2003
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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
Mark Murcko
Chemistry & Biology, 1997
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Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition
John Braganza, Huey Shieh
Bioorganic & Medicinal Chemistry Letters, 2010
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Indole-based heterocyclic inhibitors of p38α MAP kinase: designing a conformationally restricted analogue
Sarvajit Chakravarty
Bioorganic & Medicinal Chemistry Letters, 2003
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Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase
lance christie
Bioorganic & medicinal …, 2009
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Strategies to design pyrazolyl urea derivatives for p38 kinase inhibition: a molecular modeling study
Srivani Palukuri
Journal of Computer-Aided Molecular Design, 2007
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Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
Giovanna Scapin
Nature Structural Biology, 2003
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