Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial (original) (raw)

Background: Infection with Helicobacter pylori is the main cause of peptic-ulcer disease. Treatment of this infection might lower the prevalence of dyspepsia in the community and improve quality of life. Methods: Individuals aged 40-49 years with confirmed H pylori infection were randomized to receive either treatment or placebo, followed over 2 years. Findings: Of 2324 infected individuals, treatment resulted in a 5% reduction in dyspepsia prevalence but had no significant impact on quality of life. Interpretation: Community screening and treatment for H pylori produced only a modest reduction in dyspepsia and no improvement in quality of life.