Deubiquitinating Enzymes as Therapeutic Targets in Cancer (original) (raw)

Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics

Suresh Ramakrishna

Cancers

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Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition

So Ahmed

Future medicinal chemistry, 2018

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Deubiquitinating enzymes as novel anticancer targets

Michael Mattern

Future Oncology, 2007

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Emerging Potential of Therapeutic Targeting of Ubiquitin-Specific Proteases in the Treatment of Cancer

Anupama Pal

Cancer Research, 2014

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Proteasome-associated deubiquitinases and cancer

Pádraig D'Arcy

Cancer and Metastasis Reviews, 2017

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Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes

Lucas Cruz

Pharmaceuticals

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Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

Pádraig D'Arcy

Drug Resistance Updates, 2015

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Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy

Hamidreza Pazoki-toroudi

Open Biology

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Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

Charlotte Knights

ACS Chemical Biology

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Identification of an inhibitor of the ubiquitin–proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Pádraig D'Arcy

MedChemComm, 2014

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Targeting the Ubiquitin Proteasome System: Beyond Proteasome Inhibition

Gael Roue

Current Pharmaceutical Design, 2013

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Molecular pathways: translational potential of deubiquitinases as drug targets

Pádraig D'Arcy

Clinical cancer research : an official journal of the American Association for Cancer Research, 2014

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Targeting the Ubiquitin Proteasome System in Cancer

Nishi Kumari

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The Ubiquitin-Proteasome Pathway and Its Role in Cancer

Edward Gelmann

Journal of Clinical Oncology, 2005

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Deubiquitinating enzymes as cancer biomarkers: new therapeutic opportunities

Naresh Poondla, PhD

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Exploiting the Ubiquitin-Proteasome Pathway for Anticancer Drug Discovery: Unanswered Questions and Future Directions

Kenyon Daniel

Letters in Drug Design & Discovery, 2005

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Detection of ubiquitin–proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development

Mikael Altun

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012

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The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research

Halina Ostrowska

Cellular and Molecular Biology Letters, 2008

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Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor

Robert Kuchta

Journal of Biomolecular Screening, 2012

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Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention

Azhar Ali

Cancers

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Deubiquitinase inhibition as a cancer therapeutic strategy

Pádraig D'Arcy

Pharmacology & therapeutics, 2015

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Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

John Hanna

Molecular & Cellular Proteomics, 2010

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Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics

John Beutler

Cancer research, 2007

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An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

Dante Neculai, Derek Ceccarelli

Cell, 2011

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The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Sharoon Akhtar

Scientific reports, 2016

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Activity-Based Ubiquitin Probes for Investigation of Deubiquitinases

Prajwal Paudel

Comprehensive Natural Products III, 2020

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Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance

silpa narayanan

Drug Resistance Updates, 2019

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Supplementary Figures 1-8 from Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics

John Beutler

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Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Pádraig D'Arcy

Chemical Biology & Drug Design, 2015

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Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer

Anupama Pal

Breast Cancer Research, 2014

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Putting phage to work in deubiquitinase ligand discovery

Julie Maupin-furlow

Journal of Biological Chemistry, 2019

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DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

sajjad hussain

Cell cycle (Georgetown, Tex.), 2009

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Inhibition of proteasome deubiquitinating activity as a new cancer therapy

behnam sadeghi

Nature Medicine, 2011

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