Depressive and negative symptoms in schizophrenia: different effects on clinical features (original) (raw)
Related papers
Negative and depressive symptoms in schizophrenia
The British Journal of Psychiatry, 1989
Ninety-five schizophrenic patients were assessed using the Present State Examination, the Brief Psychiatric Rating Scale and the Scale for the Assessment of Negative Symptoms. Negative and depressive symptoms were frequent, and significant relationships among negative symptom complexes and depressive syndromes were noted. Retardation, lack of energy, slowness, and other symptoms of depression were significantly associated with the negative symptoms of schizophrenia. Depressed affect per se did not have a significant correlation with negative symptoms.
Acta Psychiatrica Scandinavica, 2010
Evaluating depressive symptoms and their impact on outcome in schizophrenia applying the Calgary Depression Scale. Objective: To examine depressive symptoms, their course during treatment, and influence on outcome. Method: Weekly Calgary Depression Scale for Schizophrenia ratings were performed in 249 inpatients with schizophrenia. Early response was defined as a 20% reduction in the total score of the Positive and Negative Syndrome Scale for Schizophrenia from admission to week 2, response as a 50% reduction in the total score of the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) from admission to discharge and remission according to the consensus criteria. Results: Thirty six per cent of the patients were depressed at admission, with 23% of them still being depressed at discharge. Depressed patients scored significantly higher on the PANSS negative and general psychopathology subscore, featured more impairments in subjective well-being (P < 0.0001) and functioning (P < 0.0001). They suffered from more suicidality (P = 0.0021), and had greater insight into their illness (P = 0.0105). No significant differences were found regarding early response, response, and remission. Conclusion: Patients with depressive symptoms should be monitored closely, given the burden of negative symptoms, their impairments in well-being and functioning and the threat of suicidality.
Negative symptoms in schizophrenia and depression
PubMed, 1985
This study examines the differences between the prevalence of negative symptoms in schizophrenia and Major depression, diagnosed according to RDC, using Andreasen's Scale for Assessment of Negative Symptoms, SANS. Global ratings of affective flattening, alogia, avolition and inattention were significantly higher in schizophrenics whereas anhedonia - asociality were seen as commonly in depressives also. Most negative symptoms were more common in schizophrenics. Awareness of these symptoms and reduced sexual interests were significantly more in depression. Some symptoms were common in both groups. The results indicate that negative symptoms though commonly seen in depressives also, are more frequent in schizophrenic patients.
Psychopathology, 2012
were furthermore compared using correlation and regression analyses. Results: Three factors were revealed for the CDSS and HAMD-17 factor component analysis. A very similar item loading was found for the CDSS at admission and discharge, whereas results of the loadings of the HAMD-17 items were less stable. The first two factors of the CDSS revealed correlations with positive, negative and general psychopathology. In contrast, multiple significant correlations were found for the HAMD-17 factors and the PANSS subscores. Multiple regression analyses demonstrated that the HAMD-17 accounted more for the positive and negative symptom domains than the CDSS. Conclusions: The present results suggest that compared to the HAMD-17, the CDSS is a more specific instrument to measure depressive symptoms in schizophrenia and schizophrenia spectrum disorder, especially in acutely ill patients.
The Burden of Depressive Symptoms in People with Schizophrenia
Psychiatric Clinics of North America, 2009
Depressive symptoms are recognized as an important and distinct symptom domain in schizophrenia 1 and may occur at any time during the course of the illness. 2-4 Although concurrent depressive symptoms were once considered good prognostic indicators, 5 recent research has demonstrated that depressive symptoms are poor prognostic indicators of recovery and reintegration into the community. 6 Depressive symptoms worsen quality of life 7 and increase the risk of suicide, 8 psychotic relapse, and psychiatric hospitalization. 9 The prevalence of depressive symptoms among people with schizophrenia has been reported to range from 25% to 81%, 8 depending on the treatment setting, phase of the illness, and the definition of depression. It is currently unclear what proportion of people with schizophrenia treated in usual practice settings experience at least a moderate level of depressive symptoms, whether the rates of depressive symptoms change over time, or which specific functional outcomes are more adversely affected by depressive symptoms during the course of the illness. BURDEN OF DEPRESSION IN SCHIZOPHRENIA Prospective longitudinal data on depressive symptoms among people with schizophrenia in usual care are sparse. 2,10-13 Studies have typically monitored a few outcome measures in relatively small samples of inpatients following discharge from hospitalization. Thus, studies have usually focused on vulnerable subgroups. The objectives of this study 14 were to prospectively assess the prevalence of concurrent depressive symptoms in a large and diverse group of people with schizophrenia treated in usual practice settings across the United States, and to focus on the relationships between baseline depressive symptoms and long-term functional outcomes.
Schizophrenia research, 2001
The aim of the present study is to explore the relationship between depression and psychotic symptoms of schizophrenia over the course of illness. Sixty-eight patients meeting DSM-IV criteria for schizophrenia were enrolled, 27 in an acute episode, 41 when stable. Assessments were performed using the Calgary Depression Scale for Schizophrenia (CDSS) for depression and the Positive and Negative Syndrome Scale (PANSS) for psychotic symptoms. When considering patients in an acute episode (52% depressed), the CDSS score was correlated only with the PANSS positive sub-scale score. For patients in the stable period (38% depressed), the CDSS score was correlated with positive as well as negative and general psychopathology sub-scale scores. Hence, the relationship between depression and other symptoms of schizophrenia appear to differ during different stages of illness.
Basic symptoms in stable schizophrenia: relations with functioning and quality of life
2010
Objective: Over the past few decades it has been emphasized the importance of social functioning and quality of life as a part of a multidimensional assessment of outcome in the evaluation of the impact of psychosis on patients daily lives. Their relation with schizophrenia symptoms has widely been studied, showing contrasting results. Little is known concerning their relationship with subjective experiences in schizophrenia.