Vascular tumors of bone (original) (raw)
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Skeletal Radiology, 2012
The classification of vascular bone tumors remains challenging, with considerable morphological overlap spanning across benign to malignant categories. The vast majority of both benign and malignant vascular tumors are readily diagnosed based on their characteristic histological features, such as the formation of vascular spaces and the expression of endothelial markers. However, some vascular tumors have atypical histological features, such as a solid growth pattern, epithelioid change, or spindle cell morphology, which complicates their diagnosis. Pathologically, these tumors are remarkably similar, which makes differentiating them from each other very difficult. For this rare subset of vascular bone tumors, there remains considerable controversy with regard to the terminology and the classification that should be used. Moreover, one of the most confusing issues related to vascular bone tumors is the myriad of names that are used to describe them. Because the clinical behavior and, consequently, treatment and prognosis of vascular bone tumors can vary significantly, it is important to effectively and accurately distinguish them from each other. Upon review of the nomenclature and the characteristic clinicopathological, radiographic and genetic features of vascular bone tumors, we propose a classification scheme that includes hemangioma, hemangioendothelioma, angiosarcoma, and their epithelioid variants.
A retrospective analysis of bone tumors and tumor like lesions: a hospital based study of 76 cases
International Journal of Research in Medical Sciences, 2017
Background: Globally Bone tumors constitute 0.5% of the total World Cancer Incidence. In addition to benign and malignant bone tumors there are a number of nonneoplastic lesions that present in a manner similar to neoplastic conditions. Relevant demographic features such as age, sex and skeletal site are important to come to a conclusive diagnosis. The present study aims to show the prevalence and demography of bone tumors and tumor like lesions.Methods: A total of 76 cases of Bone Tumors and Tumor like Lesions were studied. They were reviewed and analyzed for age, gender, site of tumor and histologic types. Classification was done according to WHO histologic Classification of Bone Tumors.Results: There were 49 cases of primary bone tumors and tumor Like lesions with a median age of 22 years and 27 cases of metastatic bone tumors with a median age of 56 years. Males are more commonly affected. Osteosarcomas and Chondrosarcomas are the most common primary malignant Bone Tumors.Conclu...
Incidence of bone tumors and tumor like lesions at a tertiary centre - a study of 64 cases
International Journal of Research in Medical Sciences, 2018
Background: Primary bone tumors are uncommon lesions constituting less than 1% of all cancers. Although open biopsy has high accuracy, it increases risk of tumor dissemination in patients with highly malignant tumors. FNAC eliminates the complications that may occur in surgical procedures and also gives quick results. This study was conducted to determine the spectrum and demographic characteristics of bone tumors and tumor like lesions at a tertiary care centre in western Uttar Pradesh and also to assess the role of FNAC in their diagnosis. Methods: This is a three-year, retrospective as well as a prospective study done on a total of 64 cases. All the cases were subjected to detailed history, physical examination and radiological investigations. FNAC smears were stained with Giemsa and Papanicolaou stain. H and E staining was done for histopathology. Results: Mean age affected was 26 years. Male-female ratio was 2.8:1. Out of total 64 cases of bone tumors and tumor like lesions, maximum was chondrogenic tumors (17; 26.56%), followed by osteogenic tumors (15; 23.44%). Osteochondroma (08; 47.06%), Osteosarcoma (07; 46.66%) and Aneurysmal bone cyst (04; 50.0%) were the most common chondrogenic tumor, osteogenic tumor and tumor like lesion respectively. The most common bone affected was tibia (16; 25.0%), followed by femur (15; 23.4%). Sensitivity and specificity of FNAC as a diagnostic modality were 90.0% and 91.67% respectively. Conclusions: A good correlation is observed between cytological and histological diagnoses which implies that FNAC can be used as a preliminary diagnostic approach to bone tumors, although histopathology remains the gold standard.
Ultrastructure of hemangioendothelial sarcoma of bone
Cancer, 1972
The ultrastructural findings in a case of well-differentiated hemangioendothelial sarcoma of bone are described. The tumor vessels are lined by plump endothelial cells, with a larger number of organelles than their normal counterparts. Discontinuities of the vessel wall with endothelial gaps are observed. Pericytes are present in the wall of the vessels, and some are loosely attached. A few fibroblasts and smooth muscle cells are seen. Transitional stages between fibroblasts and pericytes and between pericytes and smooth muscle cells are observed. The intervascular cellular infiltration is most likely the result of extravasation through gaps in the fragile neoplastic vessels. It is proposed that the pericytes are the main source of reticulum fibers in the tumor.
Retrospective study of tumor and tumor like lesions of the bone-Tertiary center experience
IP innovative publication pvt. ltd, 2019
Introduction: Bone tumors are important contributors for morbidity and mortality. Our hospital being, trauma and orthopedic institution, many orthopedic cases are referred to our center. We have done this study to determine the pattern of bone tumors, age and sex distribution, clinico pathological characteristics seen in our tertiary orthopedic Hospital. Materials and Methods: The study comprised of bone tumors diagnosed from January 2014 to December 2018 at Sanjay Gandhi Institute of Trauma & Orthopedics, Bangalore. Clinical and radiological details were collected from the data register. Microscopic findings were analyzed on Hematoxylin and eosin stained sections. Special stains and immunohistochemistry were done wherever essential. The bone tumors were classified based on WHO classification of bone tumors. Results: Of the 166 bone biopsies in a period of four years, 28 were malignant, 40 were benign and 14 were tumor like lesions. Most common age group was 11-20 years and were benign. Malignant tumors were common in 51-60 years age with male predominance and most of them were metastatic tumors. Conclusion: Diagnosis of bone tumors and treating them effectively reduces the morbidity and mortality as most of the tumors were benign and common in boys of younger age group. Correlation of clinico radiological features are essential for the conclusive histopathological diagnosis. This helps in planning the treatment and knowing the prognosis of the tumor.
Benign tumours and tumour like lesions of bone
JPMA. The Journal of the Pakistan Medical Association, 2018
Over the last century, there has been a remarkable development in the study of benign bone tumours. This is primarily due to the improved knowledge of the nature of these lesions and improved imaging technology. They present as a diverse group of clinical and pathological entities, which vary in their clinical behaviour and aggressiveness and, hence, multidisciplinary approach is necessary in their management. Combined opinion from an orthopaedic surgeon, radiologist and a pathologist is therefore required. Incidence of these tumours is debatable because they are often asymptomatic. Many protocols have been reported in studies with respect to the management of these tumours based on the experience of different centres and different surgeons with no set guidelines. English-language studies, including case reports, case series and systemic reviews, from PubMed, ERIC, MEDLINE, EMBASE and Cochrane Reviews databases from 2002 to 2016 were included in the current. Articles reporting all l...
American Journal of Clinical Oncology, 2014
BACKGROUND-Angiosarcoma of bone is a rare high-grade malignant vascular tumor. The literature regarding treatment and outcome of patients with this tumor is limited. We performed a two-institutional retrospective study to analyze treatment and survival of patients with angiosarcoma of bone. PATIENTS AND METHODS-We reviewed patients with the histological diagnosis of primary angiosarcoma of bone treated from 1980 to 2009. Demographic details, histology, treatment and survival were reviewed. RESULTS-38 men, 22 women (median age 54 years). Most lesions occurred in the femur and the pelvis. Metastatic disease at presentation was diagnosed in 24 patients (40%). Forty-three patients underwent surgery, with 30 of them achieving surgical complete remission (SCR). Radiotherapy (RT) was applied to 17 patients, and chemotherapy (CT) to 13/35 and 15/22 patients with localized and metastatic disease, respectively. The 5-year overall survival (OS) was 20%: 33% for patients with localized disease and 0% for metastatic patients. Higher 5-year OS was reported for patients who achieved SCR (46%) than for