Hepatic and extrahepatic malignancies in autoimmune hepatitis. A long-term follow-up in 473 Swedish patients (original) (raw)

Abstract

Background/Aims: Autoimmune Hepatitis (AIH) is a liver disease which may lead to liver cirrhosis. Cirrhosis is a wellknown risk factor for hepatocellular cancer. Lymphoma is a disease, where immune modulating drugs as well as the autoimmune disease itself may contribute to the elevated risk. The aim was to investigate the risks of malignancies in a large cohort of AIH patients.

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (22)

  1. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemi- ology and molecular carcinogenesis. Gastroenterology 2007;132:2557-2576.
  2. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005;42:1208-1236.
  3. Tsukuma H, Hiyama T, Tanaka S, Nakao M, Yabuuchi T, Kitamura T, et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993;328:1797-1801.
  4. Velazquez RF, Rodriguez M, Navascues CA, Linares A, Perez R, Sotorrios NG, et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis. Hepa- tology 2003;37:520-527.
  5. Okuda H. Hepatocellular carcinoma development in cirrhosis. Best Pract Res Clin Gastroenterol 2007;21:161-173.
  6. Nishiyama R, Kanai T, Abe J, Hara R, Watahiki Y, Sakaguchi T, et al. Hepatocellular carcinoma associated with autoimmune hepatitis. J Hepatobiliary Pancreat Surg 2004;11:215-219.
  7. Meza-Junco J, Montano-Loza AJ, Martinez-Benitez B, Kimura- Hayama E. Hepatocellular carcinoma in patients with autoim- mune liver diseases: two case reports and literature review. Ann Hepatol 2007;6:122-126.
  8. Smedby KE, Baecklund E, Askling J. Malignant lymphomas in autoimmunity and inflammation: a review of risks, risk factors, and lymphoma characteristics. Cancer Epidemiol Biomarkers Prev 2006;15:2069-2077.
  9. Alexander DD, Mink PJ, Adami HO, Chang ET, Cole P, Mandel JS, et al. The non-Hodgkin lyphomas: a review of the epidemi- ologic literature. Int J Cancer 2007;120:1-39.
  10. Werner M, Prytz H, Ohlsson B, Almer S, Bjo ¨rnsson E, Bergquist A, et al. Epidemiology and the initial presentation of autoimmune hepatitis type 1 in Sweden. A nationwide study. Scand J Gastroenterol 2008;43:1232-1240.
  11. Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, et al. International Autoimmune Hepatitis Group report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-938.
  12. Werner M, Bjornsson E, Prytz H, Lindgren S, Almer S, Broome U, et al. Autoimmune hepatitis among fertile women: strategies during pregnancy and breastfeeding? Scand J Gastroenterol 2007;42:986-991.
  13. Mattsson B, Rutqvist LE, Wallgren A. Undernotification of diagnosed cancer cases to the Stockholm cancer registry. Int J Epidemiol 1985;14:64-69.
  14. Swedish National board of Health and Welfare. Quality of death cause register. In; 2007. www.socialstyrelsen.se.
  15. Swedish National board of Health and Welfare. Cancer incidence in Sweden 2006. In; 2006. www.socialstyrelsen.se.
  16. Schwartz M, Roayaie S, Konstadoulakis M. Strategies for the management of hepatocellular carcinoma. Nat Clin Pract Oncol 2007;4:424-432.
  17. Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003;362:1907-1917.
  18. Boberg KM, Aadland E, Jahnsen J, Raknerud N, Stiris M, Bell H. Incidence and prevalence of primary biliary cirrho- sis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population. Scand J Gastroenterol 1998;33:99-103.
  19. Bergquist A, Ekbom A, Olsson R, Kornfeldt D, Loof L, Danielsson A, et al. Hepatic and extrahepatic malignancies in primary sclerosing cholangitis. J Hepatol 2002;36: 321-327.
  20. Loof L, Adami HO, Sparen P, Danielsson A, Eriksson LS, Hultcrantz R, et al. Cancer risk in primary biliary cirrhosis: a population-based study from Sweden. Hepatology 1994;20: 101-104.
  21. Floreani A, Baragiotta A, Baldo V, Menegon T, Farinati F, Naccarato R. Hepatic and extrahepatic malignancies in primary biliary cirrhosis. Hepatology 1999;29:1425-1428.
  22. Nijhawan PK, Therneau TM, Dickson ER, Boynton J, Lindor KD. Incidence of cancer in primary biliary cirrhosis: the Mayo experience. Hepatology 1999;29:1396-1398.