Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery (original) (raw)

Single-site studies have described an association between use of selective serotonin reuptake inhibitors (SSRIs) and adverse outcomes of surgery. Multicenter studies including a broad range of surgical procedures that explore rare outcomes, such as bleeding and mortality, and that account for indications for administration of SSRIs are needed. To determine whether perioperative use of SSRIs is associated with adverse outcomes of surgery in a national sample of patients. Retrospective study of patients 18 years or older who underwent major surgery from January 1, 2006, through December 31, 2008, at 375 US hospitals. We used multivariable hierarchical models to estimate associations between SSRI use and our outcomes. Pharmacy data were used to determine whether a patient received an SSRI in the perioperative period. Three hundred seventy-five US hospitals. Five hundred thirty thousand four hundred sixteen patients 18 years or older. Perioperative use of SSRIs. In-hospital mortality, l...